ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

Print Page
Email Article

Unique genetic & environmental determinants of prolonged fatigue: a twin study - Chronic Fatigue Syndrome research

  [ 118 votes ]   [ Discuss This Article ] • March 15, 1999

BACKGROUND: Prolonged fatigue syndromes have been proposed as
prevalent and disabling forms of distress that occur
independently of conventional notions of anxiety and

METHODS: To investigate the genetic and
environmental antecedents of common forms of psychological and
somatic distress, we measured fatigue, anxiety, depression and
psychological distress in 1004 normal adult twin pairs (533
monozygotic (MZ), 471 dizygotic (DZ)) over 50 years of age.

RESULTS: Familial aggregation of psychological distress,
anxiety and fatigue appeared to be due largely to additive
genetic factors (MZ:DZ ratios of 2.12-2.69). The phenotypic
correlations between the psychological measures (distress,
anxiety and depression) were moderate (0.67-0.79) and higher
than that between fatigue and psychological distress (0.38).

Multivariate genetic modelling revealed a common genetic
factor contributing to the development of all the observed
phenotypes (though most strongly for the psychological forms),
a second independent genetic factor also influenced anxiety
and depression and a third independent genetic factor made a
major contribution to fatigue alone. In total, 44% (95% CI
25-60%) of the genetic variance for fatigue was not shared by
the other forms of distress. Similarly, the environmental
factor determining psychological distress made negligible
contributions to fatigue, which was underpinned largely by its
own independent environmental factor.

CONCLUSION: This study
supports the aetiological independence of prolonged fatigue
and, therefore, argues strongly for its inclusion in
classification systems in psychiatry.

Hickie I, Kirk K, Martin N

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
Live Without Anxiety or Stress Live Without Anxiety or Stress
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map