ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage

 
Print Page
Email Article

UC Berkeley Researchers Present Findings Regarding Cognitive Health

  [ 121 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 22, 2002




BERKELEY, Calif.--Two chemicals produced in the body and available as dietary supplements may rejuvenate an aging brain. In the Feb. 19 Proceedings of the National Academy of Sciences (www.pnas.org), Bruce Ames, M.D., from the University of California, Berkeley, and his colleagues reported that acetyl-L-carnitine, an ester of the amino acid L-carnitine, and the antioxidant alpha lipoic acid may reverse the effects aging has on the brain.

Reportedly, an accumulation of oxidative damage on the brain's mitochondria, protein and nucleic acid may lead to neuronal and cognitive dysfunction. In fact, Ames calls mitochondria the "weak link in aging." In the first study (99, 4:2356-61, 2002), Ames and his colleagues found that these two supplements (mitochondrial metabolites) may improve memory tasks by reducing oxidative damage and improving mitochondrial function.

Scientists fed old rats acetyl-L-carnitine and/or alpha lipoic acid and then assessed the animals' spatial and temporal memories. Based on these results, the researchers found that supplemented rats experienced improved memory.

In addition, both metabolites reduced oxidative damage to nucleic acid, especially when given together. And in microscopic studies of the hippocampus (a region of the brain important for memory), the supplements reversed age-associated mitochondrial structural decay.

In the second study (99, 4:1876-81, 2002), the researchers found that feeding old rats high levels of acetyl-L-carnitine and/or alpha lipoic acid ameliorated destructive cognitive events such as oxidative damage and mitochondrial dysfunction.

In the third study, (99, 4:1870-5, 2002) researchers reported that feeding rats acetyl-L-carnitine together with alpha lipoic acid increased mitochondrial-supported cellular metabolism and lowered oxidative stress more than either compound alone. Because decreased cellular metabolism and increased oxidative stress are associated with getting older, this finding may prove to be significant in the fight to retain cognitive health.

Not only did the older rats do better on memory tests after taking supplements, the researchers reported, they also had more "pep." "With the two supplements together, these old rats got up and did the Macarena," Ames stated. "The brain looks better, they are full of energy--everything we looked at looks more like a young animal."

According to the researchers, alpha lipoic acid targets mitochondria to get rid of destructive free radicals while acetyl-L-carnitine boosts the activity of a damaged enzyme (carnitine acetyltransferase) that plays a key role in burning fuel for mitochondria. "Each chemical solves a different problem--the two together are better than either one alone," Ames said.

The university has already patented the use of this combo to rejuvenate cells based on earlier studies. In 1999, Ames co-founded the company Juvenon (www.juvenon.com) to license the patent from the university; the company is currently engaged in human clinical trials using the combination.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map