ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Wonderful White Tea: A Drink Fit for an Emperor

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Basic Aromatherapy to Help Balance and Calm

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Changes in platelet alpha-2-adrenoceptors in fibromyalgia (FM): effects of treatment with antidepressants

  [ 29 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 1, 1999


The aim of this study was to determine platelet
alpha(2)-adrenergic receptor (alpha(2)-AR) binding sites in
fibromyalgia both before and after treatment with sertraline
or placebo. The maximum number of binding sites (B(max)) and
their affinity (K(d)) for [(3)H]rauwolscine, a selective
alpha(2)-AR antagonist, were measured in 13 normal volunteers
and 22 fibromyalgia patients. Severity of illness was
evaluated by means of the Hamilton Depression Rating Scale
(HDRS) and dolorimetric assessments of tenderness at tender
points. Fibromyalgia patients had repeated measurements of
[(3)H]rauwolscine binding characteristics both before and
after subchronic treatment with sertraline or placebo for 12
weeks. [(3)H]rauwolscine binding K(d) values were
significantly higher in fibromyalgia patients than in normal
volunteers. There were significant inverse correlations
between [(3)H]rauwolscine binding K(d) values and duration of
illness, age and lower energy. Significantly higher
[(3)H]rauwolscine binding K(d) values were found in
fibromyalgia patients in an early phase of illness (<3 years)
than in fibromyalgia patients with a protracted illness (>3
years). Repeated administration of sertraline had no
significant effects on [(3)H]rauwolscine binding B(max) or
K(d) values. The results suggest that fibromyalgia and, in
particular, fibromyalgia in an early phase of illness, is
accompanied by lowered affinity of platelet alpha(2)-ARs.

Maes M, Libbrecht I, Delmeire L, Lin A, De Clerck L, Scharpe S,
Janca A




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map