ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

Whole-body vibration may be as effective as regular exercise

Print Page
Email Article

Changes in platelet alpha-2-adrenoceptors in fibromyalgia (FM): effects of treatment with antidepressants

  [ 29 votes ]   [ Discuss This Article ] • September 1, 1999

The aim of this study was to determine platelet
alpha(2)-adrenergic receptor (alpha(2)-AR) binding sites in
fibromyalgia both before and after treatment with sertraline
or placebo. The maximum number of binding sites (B(max)) and
their affinity (K(d)) for [(3)H]rauwolscine, a selective
alpha(2)-AR antagonist, were measured in 13 normal volunteers
and 22 fibromyalgia patients. Severity of illness was
evaluated by means of the Hamilton Depression Rating Scale
(HDRS) and dolorimetric assessments of tenderness at tender
points. Fibromyalgia patients had repeated measurements of
[(3)H]rauwolscine binding characteristics both before and
after subchronic treatment with sertraline or placebo for 12
weeks. [(3)H]rauwolscine binding K(d) values were
significantly higher in fibromyalgia patients than in normal
volunteers. There were significant inverse correlations
between [(3)H]rauwolscine binding K(d) values and duration of
illness, age and lower energy. Significantly higher
[(3)H]rauwolscine binding K(d) values were found in
fibromyalgia patients in an early phase of illness (<3 years)
than in fibromyalgia patients with a protracted illness (>3
years). Repeated administration of sertraline had no
significant effects on [(3)H]rauwolscine binding B(max) or
K(d) values. The results suggest that fibromyalgia and, in
particular, fibromyalgia in an early phase of illness, is
accompanied by lowered affinity of platelet alpha(2)-ARs.

Maes M, Libbrecht I, Delmeire L, Lin A, De Clerck L, Scharpe S,
Janca A

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
"It's Not Easy Being Green" - But It Is Healthy
Break Free From Fibromyalgia Break Free From Fibromyalgia
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map