ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Lilac Oil: More Than Just for Fragrance

Eat More Yogurt and Avoid Osteoporosis

Safflower: An Economically Important Herb That Can Benefit Humans and Animals Alike

What Is Bilberry Good For?

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Resveratrol Improves Arteries

Higher omega 3 levels linked to improved brain blood flow

 
Print Page
Email Article

Changes in platelet alpha-2-adrenoceptors in fibromyalgia (FM): effects of treatment with antidepressants

  [ 29 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 1, 1999


The aim of this study was to determine platelet
alpha(2)-adrenergic receptor (alpha(2)-AR) binding sites in
fibromyalgia both before and after treatment with sertraline
or placebo. The maximum number of binding sites (B(max)) and
their affinity (K(d)) for [(3)H]rauwolscine, a selective
alpha(2)-AR antagonist, were measured in 13 normal volunteers
and 22 fibromyalgia patients. Severity of illness was
evaluated by means of the Hamilton Depression Rating Scale
(HDRS) and dolorimetric assessments of tenderness at tender
points. Fibromyalgia patients had repeated measurements of
[(3)H]rauwolscine binding characteristics both before and
after subchronic treatment with sertraline or placebo for 12
weeks. [(3)H]rauwolscine binding K(d) values were
significantly higher in fibromyalgia patients than in normal
volunteers. There were significant inverse correlations
between [(3)H]rauwolscine binding K(d) values and duration of
illness, age and lower energy. Significantly higher
[(3)H]rauwolscine binding K(d) values were found in
fibromyalgia patients in an early phase of illness (<3 years)
than in fibromyalgia patients with a protracted illness (>3
years). Repeated administration of sertraline had no
significant effects on [(3)H]rauwolscine binding B(max) or
K(d) values. The results suggest that fibromyalgia and, in
particular, fibromyalgia in an early phase of illness, is
accompanied by lowered affinity of platelet alpha(2)-ARs.

Maes M, Libbrecht I, Delmeire L, Lin A, De Clerck L, Scharpe S,
Janca A




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map