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Are we on the threshold of a new theory of disease? Toxicant-induced loss of tolerance & its relationship to addiction & abdiction - Chronic Fatigue Syndrome and fibromyalgia related research

  [ 27 votes ]   [ Discuss This Article ]
By Miller CS • www.ProHealth.com • April 15, 1999


'Toxicant-induced loss of tolerance' (or TILT) describes a
two-step disease process in which (1) certain chemical
exposures, e.g., indoor air contaminants, chemical spills, or
pesticide applications, cause certain susceptible persons to
lose their prior natural tolerance for common chemicals,
foods, and drugs (initiation); (2) subsequently, previously
tolerated exposures trigger symptoms. Responses may manifest
as addictive or abdictive (avoidant) behaviors.

In some
affected individuals, overlapping responses to common
chemical, food, and drug exposures, as well as habituation to
recurrent exposures, may hide (mask) responses to particular
triggers. Accumulating evidence suggests that this disease
process might underlie a broad array of medical illnesses
including chronic fatigue, fibromyalgia, migraine headaches,
depression, asthma, the unexplained illnesses of Gulf War
veterans, multiple chemical sensitivity, and attention deficit
disorder.

Miller CS




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