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TNF-alpha & Chronic Fatigue Syndrome (CFS)

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 5, 1999


Based upon the clinical presentation of chronic fatigue
syndrome (CFS), we hypothesized that proinflammatory cytokines
may play a role in the pathogenesis of the disease. We
therefore undertook a retrospective cross-sectional study to
examine the role of TNF-alpha in patients with CFS. Our
results suggest a significant increase serum TNF-alpha in
patients with CFS (P<0.0001) compared to non-CFS controls.

This study supports the further examination of the role of
proinflammatory mediators in CFS. Furthermore, the clinical
testing of TNF-alpha blockers and other antiinflammatory
agents for the treatment of this disease is warranted.

Moss RB, Mercandetti A, Vojdani A




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