Borna disease virus infection in 2 family clusters of patients with Chronic Fatigue Syndrome (CFS)
January 6, 1999
A high rate of Borna disease virus (BDV) infection has been
demonstrated in patients with chronic fatigue syndrome (CFS).
Herein, we focused on BDV infection in two family clusters of
patients with CFS: a father, mother, two sons and one daughter
(family #1); and a father, mother, two daughters and one son
(family #2). All members, except for the elder son in family
#1 and the father and son in family #2, were diagnosed with
CFS. The results supported that all the family members with
CFS were infected with BDV, as evidenced by the presence of
antibodies to viral p40, p24 and/or gp18 and BDV p24 RNA in
peripheral blood mononuclear cells. The healthy members,
except for the father of family #2 who was positive for
antibody to p24, were all negative by both assays.
studies in family #1 continued to reveal BDV antibodies and
BDV RNA, except in the mother, who lost the RNA upon slight
recovery from the disease.
Nakaya T, Takahashi H, Nakamur Y, Kuratsune H, Kitani T, Machii T,
Yamanishi K,Ikuta K