ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

What Makes Spanish Marjoram Oil Special?

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

 
Print Page
Email Article

Researchers Determine a Contributing Genetic Factor of Photosensitivity in Lupus Patients

  [ 41 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 27, 2003


Discovery opens doors to treating symptom that can cause the body to attack itself

(Orlando, Florida) – Researchers at the University of Pennsylvania School of Medicine have identified a variant of the human gene for tumor necrosis factor-alpha (TNF-alpha) as the cause for photosensitivity in lupus patients. This discovery, which was presented today at the annual scientific meeting of the American College of Rheumatology, will not only help in treating photosensitivity, but will also advance research on treating this potentially damaging symptom and possibly point to one of the genetic causes of lupus.

Victoria Werth, MD Associate Professor of Dermatology and Medicine in Penn’s School of Medicine, working in collaboration with Kathleen E. Sullivan, MD, PhD, Associate Professor of Pediatrics, University of Pennsylvania School of Medicine, and attending physician in The Children's Hospital of Philadelphia Division of Allergy and Immunology, identified a variant of the TNF-alpha promoter that showed increased activity when exposed to sunlight. This discovery is crucial to understanding photosensitivity and lupus because TNF-alpha has been shown to stimulate apoptosis, the process of cellular death.

As skin cells die, intracellular proteins move to the cell’s surfaces where they stimulate an immune reaction. The immune system makes new antibodies against these proteins and triggers further inflammation, causing the body to attack its own internal organs - just from sunlight.

As part of her research, Werth has studied the effects of TNF-alpha in cultured cells and patients. She has found that a large percentage of patients with subacute cutaneous lupus erythematosus (SCLE), a highly photosensitive form of lupus, has one or even two copies of the TNF-alpha variant gene. Thus, when these cells are exposed to sunlight, the gene becomes overactive, and a large quantity of TNF-alpha is produced. This causes nearby skin cells to undergo apoptosis, therefore stimulating the immune system and triggering flares that could affect internal organs.

The increased presence of TNF-alpha in lupus patient cells suggests that additional genetic variants are associated with increased TNF-alpha production in response to sunlight. This could mean major advances in treating lupus patients.

“These results now let us think about different categories of drugs for treatment of photosensitivity,” says Werth. While drugs like antimalarials and thalidomide are already used to inhibit TNF-alpha and treat the skin manifestations of lupus, these findings allow researchers to test newer drugs that inhibit TNF-alpha. Also, as researchers better understand the wavelengths of light that trigger the disease, they can develop sunscreens that will hopefully improve the ability to block the harmful effects of sunlight.

Funding for this research was provided by the Lupus Research Institute through their Novel Research Program, which seeks to support highly promising novel approaches to discover the cause, improve the treatment and cure lupus.

Source: Press release from the University of Pennsylvania Health System (http://www.uphs.upenn.edu/news/News_Releases/oct03/lupus.htm)



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map