ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Carnitine deficiency suggested as contributor to autism

Vitamin D supplement use associated with lower risk of breast cancer

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

 
Print Page
Email Article

A study of the immunology of the Chronic Fatigue Syndrome (CFS): correlation of immunologic parameters to health dysfunction

  [ 122 votes ]   [ Discuss This Article ]
By Hassan IS, Bannister BA, Akbar A, Weir W, Bofill M • www.ProHealth.com • April 5, 1998


Surface and intracellular immunologic and apoptotic markers
and functional lymphocyte assays after stimulation with
anti-CD3/anti-CD28 antibodies or phytohemagglutinin (PHA) were
studied in 44 patients fulfilling the Oxford criteria for
chronic fatigue syndrome (CFS). Results were then correlated
to scores for the Short Form-36 health questionnaire (SF-36),
which assesses eight aspects of patient's well- being, and for
the general health questionnaire (GHQ), which detects current
psychiatric disorder. Patients had significantly increased
mean fluorescence intensity readings of HLA-DR in CD4 and CD8
cells (P < 0.05). Expression of the costimulatory receptor
CD28 in CD8 cells was significantly reduced, and the apoptosis
repressor ratio of bcl-2/bax in both CD4 and CD8 was increased
in patients (P < 0.05). Patients with increased HLA-DR
expression had significantly lower SF-36 total scores, worse
body pains, and poorer general health perception and physical
functioning scores. Increased spontaneous lymphocyte
proliferation was associated with poor general health
perception. PHA proliferative responses were lower in patients
with poor emotional and mental health scores, and the
anti-CD3/anti-CD28 response was low in those with low general
health perception scores. Higher spontaneous proliferation and
reduced PHA responses correlated with higher GHQ scores.
Similarly, GHQ scores were significantly higher, indicating
worse mental health, in those with lower total SF-36 scores
and worse general and mental health scores in the SF-36
questionnaire. Finally, higher expression of the costimulatory
molecule CD28 correlated with higher total SF-36 scores,
general health perception and social functioning scores, and
with lower role limitation due to physical health. The
increased expression of class II antigens and the reduced
expression of the costimulatory receptor CD28, which is a
marker of terminally differentiated cells, lend further
support to the concept of immunoactivation of T- lymphocytes
in CFS and may be consistent with the notion of a viral
etiopathogenesis in the illness. We report, for the first
time, increased expression of the apoptosis repressor protein
bcl-2, which may contribute to enhanced survival of activated
lymphocytes. Using the SF-36 health assessment questionnaire
and the GHQ, we demonstrated changes in different
immunological parameters, each of which correlated with
particular aspects of disease symptomatology.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map