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Cellular sequences in stealth viruses

  [ 19 votes ]   [ Discuss This Article ]
By Martin WJ • www.ProHealth.com • April 20, 1998


Cloned DNA obtained from the culture of an African green
monkey simian cytomegalovirus-derived stealth virus contains
multiple discrete regions of significant sequence homology (p
values ranging from 4 x 10(- 3) to 1 x 10(-20)) to portions of
known human cellular genes. The stealth virus was cultured
from a patient with chronic fatigue syndrome (CFS). Earlier
studies had revealed considerable sequence heterogeneity
within DNA fragments isolated from virus-infected cells. A set
of polymerase chain reaction (PCR) primers generated different
PCR products when tested on stealth virus cultures from 4
patients with CFS. Several of the PCR products also contain
regions of significant partial homology to distinct cellular
sequences, including sequences repetitively expressed
throughout the cellular genome. Stealth viruses may play an
important role in the origins and in the genetic diversity of
both viral and cellular sequences.




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