ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Low-dose hydrocortisone for treatment of Chronic Fatigue Syndrome (CFS): a randomized controlled trial

  [ 61 votes ]   [ Discuss This Article ]
By McKenzie R, O'Fallon A, Dale J, Demitrack M, Sharma G, Deloria M, Garcia-Borreguero D, Blackwelder W, Straus SE • www.ProHealth.com • September 23, 1998


CONTEXT: Chronic fatigue syndrome (CFS) is associated with a
dysregulated hypothalamic-pituitary adrenal axis and
hypocortisolemia.

OBJECTIVE: To evaluate the efficacy and
safety of low-dose oral hydrocortisone as a treatment for CFS.
DESIGN: A randomized, placebo- controlled, double-blind
therapeutic trial, conducted between 1992 and 1996.

SETTING: A
single-center study in a tertiary care research institution.
PATIENTS: A total of 56 women and 14 men aged 18 to 55 years
who met the 1988 Centers for Disease Control and Prevention
case criteria for CFS and who withheld concomitant treatment
with other medications.

INTERVENTION: Oral hydrocortisone, 13
mg/m2 of body surface area every morning and 3 mg/m2 every
afternoon, or placebo, for approximately 12 weeks.

MAIN
OUTCOME MEASURES: A global Wellness scale and other
self-rating instruments were completed repeatedly before and
during treatment. Resting and cosyntropin-stimulated cortisol
levels were obtained before and at the end of treatment.
Patients recorded adverse effects on a checklist.

RESULTS: The
number of patients showing improvement on the Wellness scale
was 19 (54.3%) of 35 placebo recipients vs 20 (66.7%) of 30
hydrocortisone recipients (P =.31). Hydrocortisone recipients
had a greater improvement in mean Wellness score (6.3 vs 1.7
points; P=.06), a greater percentage (53% vs 29%; P=.04)
recording an improvement of 5 or more points in Wellness
score, and a higher average improvement in Wellness score on
more days than did placebo recipients (P<.001). Statistical
evidence of improvement was not seen with other self-rating
scales. Although adverse symptoms reported by patients taking
hydrocortisone were mild, suppression of adrenal
glucocorticoid responsiveness was documented in 12 patients
who received it vs none in the placebo group (P<.001).

CONCLUSIONS: Although hydrocortisone treatment was associated
with some improvement in symptoms of CFS, the degree of
adrenal suppression precludes its practical use for CFS.




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map