ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Mouse running activity is lowered by Brucella abortus treatment: a potential model to study chronic fatigue

  [ 51 votes ]   [ Discuss This Article ]
By Ottenweller JE, Natelson BH, Gause WC, Carroll KK, Beldowicz D, Zhou XD, LaManca JJ • www.ProHealth.com • March 23, 1998


Chronic fatigue syndrome, which can occur after acute
infection and last for years, is characterized by severe and
persistent fatigue. Others have reported decreases in mouse
running activity following infection and have suggested this
may provide an animal model for studying chronic fatigue.
Voluntary running is a highly motivated activity in mice,
which will often run 5-7 mi/day in our laboratory. Following 2
weeks of acclimation to running wheels with food and water
available ad lib, female BALB/c mice received 0.2-mL tail vein
injections of killed Brucella abortus (BA) or saline vehicle.
Subsequently the effects on voluntary running and grooming
behavior were determined. Injection of BA caused an immediate
large decrease in running and a lack of grooming. Vehicle
injections produced no changes in behavior. After the first
several days of reduced running behavior, levels of running
and grooming slowly returned back to normal over the next 2-4
weeks, with substantial individual differences in the rate of
recovery. The pattern of running during recovery was
intriguing in that BA mice first ran at normal levels just
after the lights went out, but they stopped after only 1-2 h.
As recovery proceeded, they gradually increased the duration
of the running bout during the night. Because this model uses
voluntary exertion and the ability to run for longer periods
of time characterizes recovery, the model may be a good one
for studying the biologic underpinnings of chronic fatigue.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map