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The analgesic effects of selective serotonin reuptake inhibitors

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By Smith AJ • www.ProHealth.com • March 20, 1998


Source: J Psychopharmacol 1998;12(4):407-13

This paper endeavours to provide a critical clinical review of
the use of selective serotonin reuptake inhibitors (SSRIs) in
the management of pain. Case reports, placebo-controlled
trials and trials comparing SSRIs with tricyclic
antidepressants (TCAs) are considered. The analgesic effects
of TCAs are well known and this review suggests that there is
little evidence for their replacement by SSRIs in pain
management. There are, at present, too few comparative drug
trials to make a definitive statement, although the trend is
clearly against SSRIs.




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