ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

 
Print Page
Email Article

A New Protective Protein Against Parkinson's Disease

  [ 140 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 16, 2004


In a recent finding that broadens our understanding of axon loss in neurodegenerative disorders, researchers at the Swiss Federal Institute of Technology in Lausanne (EPFL) have shown that a spontaneous dominant mutation has a protective effect on axons in an mouse model of Parkinson's disease. Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons projecting to a well-defined structure in the brain named the striatum. The resulting failure of the nigrostriatal pathway leads to profound dopamine deficiency, causing bradykinesia, tremor and rigidity. Since the deficit in striatal dopamine is the main cause of PD symptoms, it appears critical to preserve axon terminals to ensure healthy functioning of the nigrostriatal system. Previous work had shown that a spontaneous dominant mutation in the mouse, Wlds (slow Wallerian degeneration), is associated with the protection of axons from a process known as peripheral nerve Wallerian degeneration -- that is, degeneration of axons following a physical insult that disconnects the axons from neuronal cell bodies. The Wlds mutation results in the formation of an abnormal fusion protein whose molecular effects aren't well understood, but the axonal protection conferred by the mutation suggests therapeutic potential for manipulating the biological pathways involved. In the present work, these scientists sought to assess the effects of the Wlds protein in mouse model of Parkinson's disease. The researchers found that following injection of a dopamine toxin in the brain (a technique that mimics Parkinson's Disease), Wlds mutant mice exhibited strong protection of dopaminergic axons. Moreover, the ability of the preserved axons to synthesize and release dopamine was confirmed by behavioural data. Interestingly, while axons were protected, there was no accompanying protection of the dopaminergic cell bodies in Wlds mice, highlighting subtle differences in the degeneration process between neuronal sub-cellular compartments. This newly reported Wlds-mediated protection of the dopamine axons may lead to the understanding of mechanisms underlying axon loss and to the development of new therapeutic approaches for Parkinson disease. Ali Sajadi, Bernard L. Schneider, and Patrick Aebischer: "Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease" Published in Current Biology, Volume 14, Number 4 February 17, 2004, pages 326-330. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map