ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Natural Remedies for the Prevention of Dry Eyes

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

What Makes Spanish Marjoram Oil Special?

CoQ10's Potential Capabilities for Your Health

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

8 Chia Seed Recipes

 
Print Page
Email Article

A New Protective Protein Against Parkinson's Disease

  [ 140 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 16, 2004


In a recent finding that broadens our understanding of axon loss in neurodegenerative disorders, researchers at the Swiss Federal Institute of Technology in Lausanne (EPFL) have shown that a spontaneous dominant mutation has a protective effect on axons in an mouse model of Parkinson's disease. Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons projecting to a well-defined structure in the brain named the striatum. The resulting failure of the nigrostriatal pathway leads to profound dopamine deficiency, causing bradykinesia, tremor and rigidity. Since the deficit in striatal dopamine is the main cause of PD symptoms, it appears critical to preserve axon terminals to ensure healthy functioning of the nigrostriatal system. Previous work had shown that a spontaneous dominant mutation in the mouse, Wlds (slow Wallerian degeneration), is associated with the protection of axons from a process known as peripheral nerve Wallerian degeneration -- that is, degeneration of axons following a physical insult that disconnects the axons from neuronal cell bodies. The Wlds mutation results in the formation of an abnormal fusion protein whose molecular effects aren't well understood, but the axonal protection conferred by the mutation suggests therapeutic potential for manipulating the biological pathways involved. In the present work, these scientists sought to assess the effects of the Wlds protein in mouse model of Parkinson's disease. The researchers found that following injection of a dopamine toxin in the brain (a technique that mimics Parkinson's Disease), Wlds mutant mice exhibited strong protection of dopaminergic axons. Moreover, the ability of the preserved axons to synthesize and release dopamine was confirmed by behavioural data. Interestingly, while axons were protected, there was no accompanying protection of the dopaminergic cell bodies in Wlds mice, highlighting subtle differences in the degeneration process between neuronal sub-cellular compartments. This newly reported Wlds-mediated protection of the dopamine axons may lead to the understanding of mechanisms underlying axon loss and to the development of new therapeutic approaches for Parkinson disease. Ali Sajadi, Bernard L. Schneider, and Patrick Aebischer: "Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease" Published in Current Biology, Volume 14, Number 4 February 17, 2004, pages 326-330. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map