ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

Abstract: Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK interacting protein (JIP)-1

  [ 55 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 17, 2003


J Biol Chem. 2003 Aug 13 [Epub ahead of print].

Scheinfeld MH, Ghersi E, Davies P, D'Adamio L.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.

Alzheimer's Disease (AD) is genetically linked to the processing of amyloid b protein precursor (AbPP). Aside from being the precursor of the Amyloid beta (Ab) found in plaques in the brains of patients with AD, little is known regarding the functional ro le of AbPP. We have recently reported biochemical evidence linking AbPP to the JNK signaling cascade by finding that JNK Interacting Protein-1 (JIP-1) binds AbPP.

In order to study the functional implications of this interaction we assayed the carboxyl t e rminal of AbPP for phosphorylation. We found that the threonine 668 within the AbPP Intracellular Domain (AID or elsewhere AICD) is indeed phosphorylated by JNK1.

We surprisingly found that although JIP-1 can facilitate this phosphorylation, it is not req uired for this process. We also found that JIP-1 only facilitated phosphorylation of AbPP but not of the two other family members APLP1 (Amyloid Precursor Like Protein 1) and APLP2. Understanding the connection between AbPP phosphorylation and the JNK signaling pathway which mediates the cells response to stress may have important implications in understanding the pathogenesis of Alzheimers Disease.

PMID: 12917434 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map