ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Basic Aromatherapy to Help Balance and Calm

Tea drinkers have lower glaucoma risk

Wonderful White Tea: A Drink Fit for an Emperor

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Acid Reflux May Respond Better to Foods Than Prescribed Pills

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Abstract: Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK interacting protein (JIP)-1

  [ 55 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 17, 2003


J Biol Chem. 2003 Aug 13 [Epub ahead of print].

Scheinfeld MH, Ghersi E, Davies P, D'Adamio L.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.

Alzheimer's Disease (AD) is genetically linked to the processing of amyloid b protein precursor (AbPP). Aside from being the precursor of the Amyloid beta (Ab) found in plaques in the brains of patients with AD, little is known regarding the functional ro le of AbPP. We have recently reported biochemical evidence linking AbPP to the JNK signaling cascade by finding that JNK Interacting Protein-1 (JIP-1) binds AbPP.

In order to study the functional implications of this interaction we assayed the carboxyl t e rminal of AbPP for phosphorylation. We found that the threonine 668 within the AbPP Intracellular Domain (AID or elsewhere AICD) is indeed phosphorylated by JNK1.

We surprisingly found that although JIP-1 can facilitate this phosphorylation, it is not req uired for this process. We also found that JIP-1 only facilitated phosphorylation of AbPP but not of the two other family members APLP1 (Amyloid Precursor Like Protein 1) and APLP2. Understanding the connection between AbPP phosphorylation and the JNK signaling pathway which mediates the cells response to stress may have important implications in understanding the pathogenesis of Alzheimers Disease.

PMID: 12917434 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map