ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

What Is Bitter Orange?

 
Print Page
Email Article

Testosterone May Protect Against Alzheimer's

  [ 152 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 27, 2004


Researchers Caution: It Is too Early to Recommend Testosterone Therapy for Prevention of Alzheimer' Disease By Salynn Boyles
WebMD Medical News  Reviewed By Brunilda Nazario, MD on Monday, January 26, 2004 Jan. 26, 2004 --

The evidence is mounting that testosterone may protect men against developing Alzheimer's disease, and now some experts say it may be time for hormone therapy trials to help answer the question once and for all. A newly published government study links low levels of the male sex hormone as early as a decade before a diagnosis of Alzheimer's with an increased risk for the disease.

Researchers with the National Institute on Aging (NIA) say their findings show testosterone protects the aging brain from dementia. But they add that it is far too soon to recommend testosterone therapy for the prevention of Alzheimer's disease. "There are a lot of concerns about using these supplements," investigator Susan Resnick, PhD, tells WebMD. "Many, many men in the United States are using them, but we have very little information on safety and health outcomes."

Modest Risk Reduction Resnick and NIA colleagues evaluated testosterone levels over time in 574 men participating in a large ongoing aging study. Using stored blood samples, the researchers were able to identify testosterone levels measured over an average of almost 20 years. Fifty-four of the men developed Alzheimer's disease during the study. Although testosterone levels fell over time in all men as they aged, these levels dropped more precipitously in men who later developed the disease. At the end of the study, men with Alzheimer's disease had, on average, about half the levels of testosterone as men without age-related dementia.

The researchers measured 'free' testosterone, which is the active form of the hormone in the body. For every 10-point increase in testosterone level, there was a 26% decrease in the risk of Alzheimer's disease. This was true even after adjusting for the effect of age, level of education, and other factors that may increase the risk of Alzheimer's disease. "The strength of this study was that we could go back as long as 10 years prior to a diagnosis of Alzheimer's disease and show that men with higher levels of free testosterone are less likely to develop the disease," Resnick says.

Prevention Trials The findings are published in the Jan. 27 issue of the journal Neurology. In the same issue, researchers from Italy reported that lean male and female Alzheimer's patients had low levels of free testosterone when compared with the control group. Editorialists question whether it is time for testosterone prevention trials in men. More than 1.7 million prescriptions for testosterone were written in the United States in 2002, representing a 30% increase over 2001 and a 170% increase over 1999, according to figures from the National Academy of Sciences' Institute of Medicine. Older men are increasingly taking the hormone in an effort to stop the clock and prevent conditions associated with aging, even though the medical evidence for this is weak.

Last November, an Institute of Medicine task force came out against large-scale testosterone prevention trials similar to the estrogen replacement therapy trials in women. Instead, the group recommended smaller trials involving only older men who had been diagnosed with low testosterone and who are not at high risk for prostate cancer. Just as long-term estrogen replacement therapy in older women has been linked to an increased risk of breast cancer, there are concerns that men who take testosterone may be increasing their prostate cancer risk.

Alzheimer's expert Samuel Gandy, MD, PhD, says the hope is that scientists will develop a "designer" testosterone that would target the brain and not affect other organs, in the same way the designer estrogen-like compounds, such as Raloxifene (Evista), targets the bones to prevent osteoporosis. "Theoretically we could develop a designer estrogen or testosterone that could be protective against dementia," he says.

The Alzheimer's Association spokesman, who runs the Farber Institute for Neurosciences at Philadelphia's Thomas Jefferson University, says the long-term risks vs. benefits of taking testosterone to prevent dementia will not be known until clinical trials are completed. "Until that happens there is no medical justification for taking testosterone to lower the risk of Alzheimer's," he says. "The data just aren't there to support that as a recommendation."

SOURCES: Moffat et al. Neurology, Jan. 27, 2004; vol 62: pp 188-193. Paoletti et al. Neurology, Jan. 27, 2004; vol 62: pp 301-303. Institute of Medicine press release on testosterone trials, November 2003. Susan M. Resnick, PhD, National Institute on Aging, Baltimore, Md. Samuel Gandy, MD, PhD, spokesman, Alzheimer's Association; professor of neurology, Thomas Jefferson University, Philadelphia; director, Farber Institute. © 2003 WebMD Inc. All rights reserved.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map