Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Best Herbs to Help With Insomnia

 
Print Page
Email Article

Jefferson Neuroscientists Studying New Type of Alzheimer’s Drug Aimed at Halting Disease Progression

  [ 481 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 2, 2004


Researchers hope Alzhemed will prove effective in international clinical trial

Neuroscientists at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia will begin a clinical trial testing a new type of drug that attacks amyloid, the protein substance that accumulates in the brains of Alzheimer’s disease patients. The buildup of amyloid and the formation of tangles and plaques in the brain are thought to be major causes of the mind-robbing ravages of Alzheimer’s disease.

Jefferson University and professor of psychiatry and neurology at Jefferson Medical College, and Samuel Gandy III, M.D., Ph.D., director of the Farber Institute for Neurosciences and professor of neurology and biochemistry and molecular pharmacology at Jefferson Medical College, are participating in a multicenter clinical trial to examine the effectiveness of a drug, Alzhemed, in halting the development of amyloid plaques – and the progression of the disease – in individuals with mild to moderate Alzheimer’s.

Currently available medications such as Aricept, Reminyl, Exelon and Namenda treat only disease symptoms, explains Dr. Rovner. Alzhemed is designed to act differently. “What’s exciting about Alzhemed is that it works directly on the amyloid protein,” says Dr. Rovner. Alzhemed is being investigated as a “disease-modifying” medication, he notes, with the objective to change the disease. “The hope is that it stabilizes the course of the disease, modifying its progression,” Dr. Rovner says. “It’s aimed at what is thought to be the central problem in the disease – the buildup of protein in the brain that disrupts its message system.”

The drug actually physically combines with amyloid to prevent plaque formation. It also is expected to inhibit the inflammatory response associated with amyloid buildup in Alzheimer’s. Drs. Rovner and Gandy will lead the Jefferson participation in the trial. The trial is scheduled to last 18 months, and will enroll about 950 Alzheimer's patients with a mild-to-moderate form of the disease. About 50 centers in the United States and 20 in Canada will participate.

Jefferson will enroll approximately 15 patients. Participants are randomized to one of three treatment arms in the trial. One group of patients will receive 100 mg of Alzhemed twice a day. Another group will receive 150 mg of Alzhemed twice a day, while a third group will get a placebo. The trial is double blind, meaning neither the participants nor the doctors know who is receiving treatment. To be eligible, patients need to be on one of the existing Alzheimer’s medications for four months. Potential participants are screened for eligibility using a cognitive skills test.

“What is unique about this trial is its length – 70 weeks,” says Dr. Rovner. “Most drug trials don’t last that long, but because we are investigating Alzhemeds’ impact on disease course, the extended followup is necessary to examine more precisely whether a disease-modifying effect occurs,” he adds. There currently is no effective medication to treat Alzheimer's, which affects more than 4.5 million people in the United States alone, a figure expected to triple as the population ages. The disease gradually destroys memory and the ability to think.

Current U.S. Food and Drug Administration-approved drugs called cholinesterase inhibitors don’t work on the amyloid protein, Dr. Rovner explains. They block enzymes that degrade acetylcholine, a neurotransmitter important for memory in the central nervous system. They treat the symptoms, not the underlying disease. Four drugs – Aricept, Exelon, Reminyl and Tacrine – are approved to treat the symptoms of mild-to-moderate Alzheimer’s. A fifth drug, Namenda, which works on a different neurotransmitter, was approved last year for moderate-to-severe cases.

Dr. Gandy, who is also vice chair of the Alzheimer’s Association’s Medical and Scientific Advisory Council, explains that a natural substance in the body called glycosaminoglycan binds to amyloid protein and facilitates amyloid sticking together to form plaques. Alzhemed binds amyloid instead and prevents the glycosaminoglycan from promoting amyloid deposition. It reduces the amount of amyloid in the central nervous system’s cerebrospinal fluid, which bathes the brain and spinal cord.

To date, there have been no serious side effects related to Alzhemed reported, although some people have had mild, transient nausea or vomiting. “Presumably,” Dr. Gandy says, “an Alzheimer’s patient would take the drug for the rest of his or her life.” The success of failure of the trial will be measured in periodic cognitive skills monitoring before, during and after the 70 weeks. The researchers will also examine brain volume by magnetic resonance imaging before and after the trial.

The trial is funded by Neurochem, Inc., a drug development company headquartered in Laval, Canada.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
How Glutathione Can Save Your Life How Glutathione Can Save Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map