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Comparison of heart rate variability in patients with Chronic Fatigue Syndrome (CFS) & controls

  [ 26 votes ]   [ Discuss This Article ]
By Yataco A, Talo H, Rowe P, Kass DA, Berger RD, Calkins H • www.ProHealth.com • December 8, 1997


Recent studies have reported a close association between chronic
fatigue syndrome and neurally mediated hypotension. We
hypothesized that this association may result from an
abnormality in autonomic function among patients with chronic
fatigue syndrome, which may be detectable using an analysis of
heart rate variability. We prospectively studied 19 patients
who fulfilled the Centers for Disease Control criteria for
chronic fatigue syndrome and 11 controls. Each subject
underwent a two-stage tilt-table test while wearing a Holter
monitor. Heart rate variability was assessed in the supine
baseline position and during upright tilt using frequency
domain parameters. In the baseline supine position, high
frequency (HF) power, low frequency (LF) power, and the ratio
of low frequency power to high frequency power (LF/HF ratio)
were similar. In both patient groups, upright tilt resulted in
a similar decrease in HF power, increase in LF power, and
increase in the LH/HF ratio. In conclusion, autonomic
function, as assessed using an analysis of heart rate
variability, does not differ in the baseline supine state, nor
in response to upright tilt among patients with chronic
fatigue syndrome and healthy controls.




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