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Autoantibodies in patients with silicone implants

  [ 40 votes ]   [ Discuss This Article ]
By Bridges AJ, Anderson JD, Burns DE, Kemple K, Kaplan JD, Lorden T • www.ProHealth.com • March 10, 1996


We assessed the prevalence of autoantibodies in women with
silicone implants and controls. Five hundred consecutive
patients with silicone implants, 25 age-matched normal women,
25 women with silicone implants and no rheumatic symptoms,
and 100 women with fibromyalgia were tested.
Immunofluorescence antinuclear antibodies (ANA) were
performed using HEp-2 cells. Subtype autoantibodies were
performed by enzyme-linked immunoassay and Western blot. ANA
tests were positive in 30% of patients with silicone implants
and rheumatic symptoms, 8% of age-matched normal women, 28%
of women with silicone implants without clinical symptoms,
and 25% of women with fibromyalgia and no silicone implants.
The predominant ANA pattern was speckled (55%). ANA subtype
testing was positive in 4.8% of patients and none of the
controls. We conclude that a larger proportion of women with
silicone implants have autoantibodies compared to age-matched
asymptomatic women suggesting immune activation in women with
silicone implants.




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