ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Neurohormonal perturbations in fibromyalgia (FM)

  [ 101 votes ]   [ Discuss This Article ]
By Crofford LJ, Engleberg NC, Demitrack MA • www.ProHealth.com • May 10, 1996


Fibromyalgia (FM) falls into the spectrum of what might be termed
'stress-associated syndromes' by virtue of frequent onset
after acute or chronic stressors and apparent exacerbation of
symptoms during periods of physical or emotional stress.

Patients with FM exhibit disturbances of the major
stress-response systems, the HPA axis and the sympathetic
nervous system. Integrated basal cortisol levels measured by
24-hour urine-free cortisol are low. FM patients display a
unique pattern of HPA axis perturbation characterized by
exaggerated ACTH response to exogenous CRH or to endogenousactivators of CRH such as insulin-induced hypoglycaemia.

The cortisol response to increased ACTH in these stress paradigms
is blunted, as is the the cortisol response to exercise.

Functional analysis suggests that FM patients may also
exhibit disturbed autonomic system activity. For example,
plasma NPY, a peptide co-localized with norepinephrine in the
sympathetic nervous system, is low in patients with FM.

Abnormalities of related neuronal systems, particularly
decreased serotonergic activity, may contribute to the
observed neuroendocrine perturbations in FM. Finally, other
neuroendocrine systems, including the growth hormone axis,
are also abnormal in FM patients. Many clinical features of
FM and related disorders, such as widespread pain and
fatigue, could be related to the observed neuroendocrine
perturbations. This hypothesis is supported by the
observation that many useful treatments for FM affect the
function of these central nervous system centres.

Further clarification of the role of neuroendocrine abnormalities in
patients with FM, and the relationship of these disturbances
with particular symptoms, may lead to improved therapeutic
strategies. {MCMStrSt}




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map