ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

What Benefits Can You Derive From Patchouli Oil?

Astaxanthin Is a Longevity Promoter

VIDEO: The Top Signs of Vitamin B1 Deficiency

 
Print Page
Email Article

Neurohormonal perturbations in fibromyalgia (FM)

  [ 101 votes ]   [ Discuss This Article ]
By Crofford LJ, Engleberg NC, Demitrack MA • www.ProHealth.com • May 10, 1996


Fibromyalgia (FM) falls into the spectrum of what might be termed
'stress-associated syndromes' by virtue of frequent onset
after acute or chronic stressors and apparent exacerbation of
symptoms during periods of physical or emotional stress.

Patients with FM exhibit disturbances of the major
stress-response systems, the HPA axis and the sympathetic
nervous system. Integrated basal cortisol levels measured by
24-hour urine-free cortisol are low. FM patients display a
unique pattern of HPA axis perturbation characterized by
exaggerated ACTH response to exogenous CRH or to endogenousactivators of CRH such as insulin-induced hypoglycaemia.

The cortisol response to increased ACTH in these stress paradigms
is blunted, as is the the cortisol response to exercise.

Functional analysis suggests that FM patients may also
exhibit disturbed autonomic system activity. For example,
plasma NPY, a peptide co-localized with norepinephrine in the
sympathetic nervous system, is low in patients with FM.

Abnormalities of related neuronal systems, particularly
decreased serotonergic activity, may contribute to the
observed neuroendocrine perturbations in FM. Finally, other
neuroendocrine systems, including the growth hormone axis,
are also abnormal in FM patients. Many clinical features of
FM and related disorders, such as widespread pain and
fatigue, could be related to the observed neuroendocrine
perturbations. This hypothesis is supported by the
observation that many useful treatments for FM affect the
function of these central nervous system centres.

Further clarification of the role of neuroendocrine abnormalities in
patients with FM, and the relationship of these disturbances
with particular symptoms, may lead to improved therapeutic
strategies. {MCMStrSt}




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map