ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

Neurohormonal perturbations in fibromyalgia (FM)

  [ 101 votes ]   [ Discuss This Article ]
By Crofford LJ, Engleberg NC, Demitrack MA • www.ProHealth.com • May 10, 1996


Fibromyalgia (FM) falls into the spectrum of what might be termed
'stress-associated syndromes' by virtue of frequent onset
after acute or chronic stressors and apparent exacerbation of
symptoms during periods of physical or emotional stress.

Patients with FM exhibit disturbances of the major
stress-response systems, the HPA axis and the sympathetic
nervous system. Integrated basal cortisol levels measured by
24-hour urine-free cortisol are low. FM patients display a
unique pattern of HPA axis perturbation characterized by
exaggerated ACTH response to exogenous CRH or to endogenousactivators of CRH such as insulin-induced hypoglycaemia.

The cortisol response to increased ACTH in these stress paradigms
is blunted, as is the the cortisol response to exercise.

Functional analysis suggests that FM patients may also
exhibit disturbed autonomic system activity. For example,
plasma NPY, a peptide co-localized with norepinephrine in the
sympathetic nervous system, is low in patients with FM.

Abnormalities of related neuronal systems, particularly
decreased serotonergic activity, may contribute to the
observed neuroendocrine perturbations in FM. Finally, other
neuroendocrine systems, including the growth hormone axis,
are also abnormal in FM patients. Many clinical features of
FM and related disorders, such as widespread pain and
fatigue, could be related to the observed neuroendocrine
perturbations. This hypothesis is supported by the
observation that many useful treatments for FM affect the
function of these central nervous system centres.

Further clarification of the role of neuroendocrine abnormalities in
patients with FM, and the relationship of these disturbances
with particular symptoms, may lead to improved therapeutic
strategies. {MCMStrSt}




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map