ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Hormone Replacement Therapy (HRT) May Be Associated with Increased Ovarian Cancer Risk

  [ 10 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 2, 2002




A study of Swedish women suggests that some forms of hormone replacement therapy (HRT) are associated with a modest increase in risk of epithelial ovarian cancer. The findings appear in the April 3 issue of the Journal of the National Cancer Institute.

Tomas Riman, M.D., of Falu Hospital and Karolinska Institute in Sweden, and his coworkers report that the use of both estrogens and estrogens combined with a sequential, or cyclic, regimen of progestins was associated with an increased risk of epithelial ovarian cancer. However, use of estrogens combined with a continuous, or daily, regimen of progestin was not associated with increased ovarian cancer risk.

Estrogen replacement therapy, which helps relieve symptoms of menopause and may prevent osteoporosis and heart disease, has been associated with an increased risk of uterine cancer. In women with an intact uterus, combining estrogens with progestins has been shown to reduce this risk.

Results of epidemiologic studies looking at estrogen replacement therapy and the risk of ovarian cancer have not been as clear. The authors point out that most studies that examined hormone replacement therapy and ovarian cancer did so without indicating whether estrogens were taken alone or supplemented with progestins.

In the new study, Riman and his coworkers identified 655 women with epithelial ovarian cancer from Swedish cancer registries, along with 3,899 cancer-free women. The women, who were between the ages of 50 and 74, completed questionnaires about their history of HRT use and other factors that may have affected their risk of ovarian cancer.

The authors found that women who had used estrogens alone had a 43% increased risk of developing epithelial ovarian cancer compared with women who had never used such therapy. However, this risk increase was seen only in women with an intact uterus. Women who had undergone hysterectomies and had used estrogens were not at increased risk of ovarian cancer.

Moreover, women who had used estrogens combined with sequential progestins had a 54% increased risk of developing epithelial ovarian cancer compared with women who had never used this type of therapy. Women who had used estrogens combined with continuous progestins did not appear to have an increased risk of ovarian cancer.

While the greatest risk increases were seen in women who had used either form of HRT for more than 10 years, the authors caution that the increase in risk is modest. They note that, of 1,000 women taking estrogens alone or with sequential progestins, only two or three will develop ovarian cancer as a result. In Sweden, one out of 100 women between the ages of 50 and 75 will develop ovarian cancer regardless of HRT use.

Consequently, the authors do not recommend changing current prescribing practices: “For women to make an informed decision about whether or not to use HRT, all beneficial and adverse hormonal aspects concerning [breast cancer,] osteoporosis, coronary heart disease, venous thrombosis, and other health effects must be addressed.”

However, they write, “if our findings are replicated it would be valuable to consider the epithelial ovarian cancer risk increase associated with the use of certain HRT regimens, especially given the prevalence of HRT use and the poor prognosis of epithelial ovarian cancer.”


Contact: Tomas Riman, M.D., Falu Hospital, 46 23 490565; fax: 46 23 490989, tomas.riman@ltdalarna.se (On April 3 from 7 a.m. to 4 p.m. GMT: Department of Medical Epidemiology, Karolinska Institute, 46 8 7286160; fax: 46 8 314957)

Riman T, Dickman PW, Nilsson S, Correia N, Nordlinder H, Magnusson, CM, et al. Hormone-replacement therapy and the risk of invasive epithelial ovarian cancer in Swedish women. J Natl Cancer Inst 2002;94:497–504.

Source: Journal of the National Cancer Institute



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map