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Correlates of fatigue in HIV infection prior to AIDS: a pilot study

  [ 19 votes ]   [ Discuss This Article ] • May 12, 1996

Fatigue is widely recognized as a significant source of morbidity in
persons with human immunodeficiency virus (HIV) infection, yet
there are few data examining fatigue in this population. We
present pilot data assessing the relationship between fatigue
and various physical and psychosocial measures in 20 men with
HIV infection prior to the clinical development of acquired
immunodeficiency syndrome (AIDS). Fatigue was measured by a
visual analogue scale (VAS) and the Fatigue Assessment
Inventory (FAI). No statistically significant associations
were found between fatigue measures and physical parameters
including haemoglobin, haematocrit, albumin, total protein,
and physical dimension score of the Sickness Impact Profile
(SIP). The FAI correlated well with Beck's Depression
Inventory and SIP-Psychosocial Dimension (r = 0.72 and 0.81,
respectively; p < 0.001.) Both the FAI and VAS held moderate
associations with the total SIP score. The SIP profile was
similar to that observed in a sample of persons with chronic
fatigue but without HIV infection, reported previously.
Although the sample size is small, our data suggest a
stronger association with psychosocial, rather than physical,
parameters among persons with HIV infection and fatigue. The
implications for clinical management and further research are

O'Dell MW, Meighen M, Riggs RV

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