ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Tests Results Promising for New Class of Osteoarthritis Drug

  [ 53 votes ]   [ Discuss This Article ] • January 10, 2001

A new class of anti-inflammatory agent, the COX/LO inhibitor, had successful and safe results in two recent phase II clinical trials. The compound known as ML3000 is being developed as a treatment for osteoarthritis in the United States.

ML3000, an anti-inflammatory, works by inhibiting the enzymes cyclooxygenase (COX) and 5-lipoxygenase (LOL), hence the name COX/LO inhibitor. Several studies have demonstrated that the anti-inflammatory and pain-relieving abilities of the agent in osteoarthritis (OA) sufferers is comparable to conventional NSAIDs (Non-steroidal anti-inflammatory drugs) and Cox-2 inhibitors.

An additional benefit of this new type of drug is that the usual levels of gastrointestinal side-effects associated with traditional Cox-2 inhibitors were not experienced in the studies. The main side-effects noted with ML300 were diarrhea and abdominal pain.

According to a report in Business Wire, ML3000 is unique because it allows for a well-balanced inhibition of both key enzymes involved in the inflammatory process – Cox and LO. This is important, the report explains, since ML3000 inhibits both Cox-1 and Cox-2 non-selectively, yet is then able to accommodate the body’s physiologic reaction to Cox inhibition. This reaction is to shunt over to the LO pathway of the arachidonic acid cascade. ML3000 blocks the effects of this shunt by additionally blocking LO.

This shunt protection is a vital factor in the way that ML3000 works. LO stimulates the production of a substance called leukotriene, which is the cause of GI damage. When LO is inhibited, leukotriene production is also inhibited, resulting in a decreased risk of GI damage.

In the first study, 107 patients with OA received either ML300 at various doses or placebo for four weeks. Participants receiving ML3000 reported a decrease in the severity of their OA symptoms.

In a second study, 404 OA patients received either ML3000, diclofenac (a type of NSAID) or placebo for four weeks. The OA patients experienced an improvement in pain and mobility, compared to those who were given placebo. The scores were the same for the ML3000 and diclofenac group.

Merckle, a pharmaceutical company, discovered ML3000 and is partnering with Forest Laboratories for the licensing and development of the drug. A spokesman for Forest labs said, “New treatments to manage osteoarthritis are needed because there are many patients who are not adequately treated with the available current medications.” The new partnership will enable phase III testing to go ahead, which the company hopes “might well demonstrate that COX/LO inhibition will result in new pharmaceuticals better suited to the needs of patients than such drugs as the recently introduced COX-2 inhibitors.”

Osteoarthritis is a degenerative joint disease affecting more than 16 million Americans and is the most common form of arthritis.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map