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Lyme disease

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www.ProHealth.com • July 3, 1994


In the United States, Lyme disease is the most common
arthropod-borne infection. The majority of cases occur in the
Northeast, the Midwest, and California, which are areas with
established foci of Borrelia burgdorferi. Phenotypic and
genotypic diversity of B. burgdorferi has resulted in its
classification into three separate genospecies and may account
for differences in disease expression. Clinical features of
Lyme disease have expanded to include a flulike illness
without erythema migrans and the persistence of intrathecal
antibody responses after successful antibiotic therapy in
neuroborreliosis. Better understanding of the pathogenic
mechanisms of Lyme arthritis will help guide future treatment
decisions, and recent progress made in assessing the risk of
infection from tick bites and vaccine development may help
calm public anxiety about Lyme disease.

Evans J




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