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Mild adrenocortical deficiency, chronic allergies, autoimmune disorders & the Chronic Fatigue Syndrome (CFS): a continuation of the cortisone story

  [ 83 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 2, 1994


The possibility that patients with disorders that improve with
administration of large, pharmacologic dosages of
glucocorticoids, such as chronic allergies and autoimmune
disorders, might have *mild deficiency of cortisol production
or utilization* has received little attention. Yet evidence
that patients with rheumatoid arthritis improved with small,
physiologic dosages of cortisol or cortisone acetate was
reported over 25 years ago, and that patients with chronic
allergic disorders or unexplained chronic fatigue also
improved with administration of such small dosages was
reported over 15 years ago, suggesting that these disorders
might be associated with mild adrenocortical deficiency. The
apparent reasons for the failure of these reports to be
confirmed or mentioned in medical textbooks and the facts
needed to restore perspective are reviewed, and the need for
further studies of the possible relationship of a mild
deficiency of the production or utilization of cortisol and
possibly other normal adrenocortical hormones to the
development of these disorders is discussed.

Jefferies WM




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