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Effect of an antidiencephalon immune serum on pain & sleep in primary fibromyalgia (FM)

  [ 42 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 3, 1994


The results of a double-blind, randomized, therapeutical trial
with SER282, an antidiencephalon immune serum (Serolab,
Lausanne, Switzerland), in 36 women, aged 24-56 years, with
primary fibromyalgia are presented. Treatment was ambulatory
and consisted of either SER282 (20 mg/ml) or amitryptiline
(AMI, 50 mg) or placebo (PL) over an 8-week treatment course.
Clinical and sleep EEG polygraphic data were obtained at
baseline and after 4 and/or 8 weeks of therapy. Compared to an
important PL response and moderate analgesia with AMI, pain
and associated symptoms improved moderately with SER282. In
contrast, polysomnographic recordings showed that SER282
tended to promote stage 4 sleep, while AMI and PL had few--if
any--effect on sleep. These results are discussed together
with the clinical characteristics of the patients and the
relations between pain, associated symptoms, and sleep
parameters in our patient population.

Kempenaers C, Simenon G, Vander Elst M, Fransolet L, Mingard P, de
Maertelaer V, Appelboom T, Mendlewicz J




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