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Viral studies of Chronic Fatigue Syndrome (CFS)

  [ 25 votes ]   [ Discuss This Article ] • January 3, 1994

Chronic fatigue syndrome (CFS) has many characteristics suggesting
persistent fatigue following a viral illness. At least nine
different RNA and DNA viruses have been considered to be
associated with this disease, but none of these viruses has
been found to be the etiologic agent. Immunologic studies have
demonstrated activated CD8+ cells and reduced function of
natural killer cells suggesting a host response to an
infection that has led to persistent immune disorders. Some of
the symptoms of CFS may be due to cytokines produced by this
hyperactive immune response to a virus that is still present
in the host or that has been eliminate but leaves abnormal
immunologic sequelae. These possibilities offer directions for
future studies of CFS and therapeutic approaches to this

Levy JA

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