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Abnormal arginine-vasopressin secretion & water metabolism in patients with postviral fatigue syndrome

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www.ProHealth.com • March 2, 1993


Water metabolism and the responses of the neurohypophysis to changes
in plasma osmolality during the water loading and water
deprivation tests were studied in nine patients with postviral
fatigue syndrome (PVFS) and eight age and six-matched healthy
control subjects. Secretion of arginine-vasopressin (AVP) was
erratic in these patients as shown by lack of correlation
between serum and urine osmolality and the corresponding
plasma AVP levels. Patients with PVFS had significantly low
baseline arginine-vasopressin levels when compared with
healthy subjects. Patients with PVFS as a group also showed
evidence of increased total body water content. These results
may be indicative of hypothalamic dysfunction in patients with
PVFS.

Bakheit AM, Behan PO, Watson WS, Morton JJ




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