ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

How Effective are Opioids in Chronic Pain Relief?

  [ 36 votes ]   [ 1 Comment ] • May 30, 2001

Fentanyl skin patches achieve better pain relief and an enhanced quality of life than sustained release oral morphine, say patients with chronic non-cancer pain in a study in the British Medical Journal.

Patients with chronic non-cancer pain, requiring continuous treatment with potent opioids, were randomly assigned to two groups to assess their treatment preference, pain control, and quality of life. One group received four weeks of treatment with sustained release oral morphine followed by fentanyl patches for four weeks. The second group received the same treatments but in reverse order.

Of 212 patients, 138 (65%) preferred fentanyl patches, whereas 59 (28%) preferred sustained release oral morphine and 15 (7%) expressed no preference. The main reason given for preferring fentanyl was better pain relief, followed by greater convenience and fewer adverse events.

Patients receiving fentanyl also had higher overall quality of life scores than patients receiving morphine. Although the level of adverse events was similar in both treatment groups, more patients experienced constipation with morphine than with fentanyl. These findings confirm that potent opioids can provide satisfactory pain relief for the difficult clinical problem of chronic non-cancer pain, conclude the authors.

In an accompanying editorial, pain specialist Henry McQuay acknowledges that this is a welcome trial in a difficult area, but writes: "Unfortunately the design of the trial means that we have to question the results. Rule one of drug trials that compare different formulations and use subjective outcomes such as patient preference is that the comparison should be done double blind."

However, the authors argue for simple clinical trials based in clinical practice, using outcomes of greater relevance to patients. The ethics of perfect design with placebos and blinding is questionable, especially when such complex trials fail to recruit patients or yield useful results. Treatment options for these patients are limited. As such, this comparative trial may herald a new approach for their care and in ethical clinical trial design.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

patch or slow release opioides
Posted by: Bob-Learner
Apr 9, 2009
I am suffering from chronique pain for 14 years and I have tried the patches for a short time and found them effective and to have a little less side effects. My skin reacted to the patch so I would move the place where the patch would go. Workers compensation choose for me the slow realease opioids because they cost less. However I must add that slow release opîoid I use is a lot better than some other similar products I tried but both superior to regular opioid that go my mood to go up and down every 4 hours or less.
Reply Reply
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Safely Burn Away Body Fat Safely Burn Away Body Fat
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map