ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

A Little Zinc Goes a Long Way

Vitamin D deficiency increases risk of chronic headache

Get the Most From Your Green Tea

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Long-Distance Command Sends Human Growth Hormone into Action

  [ 21 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 14, 2002




(Philadelphia, PA) -- Scientists have long sought to determine what agent controls the production of the human growth hormone hGH, which is vital for proper physical development.

Now, in findings that point toward an eventual gene therapy for the type of dwarfism that results when the pituitary gland is unable to manufacture the hormone, scientists at the University of Pennsylvania School of Medicine have found the mechanism that sets hGH in action. In addition, they've discerned an unusual pattern of activation in which the key mechanism operates by remote control. Their research will appear in the Friday, February 15, issue of the journal Molecular Cell. Working with transgenic mice, the Penn researchers were able to pinpoint the activation mechanism at location called hypersensitive site 1 (HS1), within the "locus control region" 15 kilobases from the hGH gene. A kilobase is a measurement representing a unit of nucleic acid. Within the microscopic realm of cells, this activation is the equivalent of unlocking the front door of a house from seven buildings away. "What we found is surprising because most genes are controlled by a promoter element adjacent to the gene, or within the gene's proximity. But in the case of this human growth hormone, the controlling mechanism is so far away there is an intervening gene between hGH and the activation site," said Stephen Liebhaber, MD, Professor of Genetics and Medicine. He is corresponding author for the study along with Nancy Cooke, MD, Professor of Medicine in the Division of Endocrinology, Diabetes and Metabolism.

The human gene cluster containing hGH includes five separate human growth genes, four of which have importance during fetal development. Only the gene hGH functions following birth, and is necessary for normal growth: Without it, humans develop a condition called pituitary dwarfism, in which their physical stature never reaches five feet.

Liebhaber, Cooke and their colleagues at Penn have been researching hGH in a series of studies and were the first to demonstrate that, unlike most hormones, hGH cannot be "turned on" merely by activating a nearby promoter element. In the present study, they've established that activating HS1 triggered a series of enzymatic changes spanning the layer of proteins and DNA (chromatin) that separate the hypersensitive activation site from the hormone promoter, eventually affecting the promoter, and ultimately opening the growth hormone itself.

"The modifications migrate through the chromatin in some way that we do not yet understand," Cooke said. Added Liebhaber, "Now we're studying the mechanism through which this signal spreads." Yugong Ho, PhD, the lead author on the paper, and Felice Elefant, PhD, both post-doctoral fellows at Penn, worked with Liebhaber and Cooke on the research.


The study was funded by the National Institutes of Health's National Institute of Child Health and Human Development.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map