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Late and Chronic Lyme Disease: Symptom Overlap with Chronic Fatigue Syndrome & Fibromyalgia

  [ 1426 votes ]   [ 28 Comments ] • May 15, 2002

By Sam Donta,M.D.


Following the introduction of Borrelia burgdorferi into the skin
by an infected tick, the organisms begin to spread both locally
and systemically. Several days typically elapse before the
appearance of the first sign of infection, i.e., erythema
chronicum migrans (ECM), or other less typical rashes (29).

The rash occurs in fewer than 50% of patients with Lyme Disease
(8,10), but the true incidence of Lyme Disease in the absence
of a rash is unknown.

The occurence of multiple rashes is indicative of systemic spread
of the organisms. Multiple rashes usually do not occur until 2-4 weeks following the initial tick bite. This is the same time
period during which the organisms are being disseminated to their
target tissues and cells. The incidence of multiple rashes was
initially reported to occur in as many as 50% of cases, but has
been much less common in the last two decades, probably because
of frequent use of antibiotics.

Approximately 4-6 weeks following the tick bite, the first
systemic symptoms (other than multiple rashes) occur in some
patients, usually in the form of "flu" (15). These symptoms
include sore throat, severe headaches and neck aches, and severe
fatigue. Rhinitis, sinusitis, and cough are not usually present,
distinguishing this "flu" from other influenza-like illnesses.
While the Lyme-flu symptoms can spontaneously resolve, patients can experience recurrent "flu".

Soon after the onset of Lyme-flu, fatigue, arthralgias and/or
myalgias may begin. The arthralgias appear to primarily involve
the large joints (i.e., knees, elbows, hips, shoulders), although
smaller joints (e.g., wrists, hands, fingers, toes) may be
involved(29). Some patients may have actual arthritis, often oligoarticular, more frequently in men than in women. Earlier estimates were that 50-75% of patients who developed late Lyme Disease had arthritis, but more recent analyses suggest that the incidence of actual arthritis in patients with late or chronic disease is closer to 25% (33).

Neck stiffness is common. The pains are described as severe, jumping from joint to joint, and may be present for only short periods of time. Pain in the teeth or in the temporal-mandibular joints is not uncommon. Rib and
chest pains occur frequently, leading some patients to seek care
in emergency rooms and urgent care centers for evaluation of
possible cardiac disease. Frequently as well are paresthesias such
as burning, numbness and tingling, and itching. Some patients
experience crawling sensations, vibrations, or electric shock-like
sensations. Rarely is there any actual palsy of the affected areas, making this much more of a neurosensory, rather than a motor, disease.

In addition to paresthesias, purely neurological symptoms and signs include headaches, an aseptic meningitis, facial nerve (Bell's)
palsy, and encephalitis or encephalopathy that may be manifested by cognitive dysfunction, especially short-term memory loss, and
psychiatric symptoms such as panic, anxiety, or depression (14).
The aseptic meningitis and Bell's palsy tend to occur within the
first few months following the tick bite, but may also occur as
part of reactivation disease (9).

Other symptoms may include fevers (usually low grade, but may be high), sweats (which may be severe), visual dysfunction (described
primarily as blurriness, but can include optic neuritis or uveitis),
tinnitus, sensitivity to sounds, or hearing loss. Shortness of
breath, palpitations and/or tachycardia, abdominal pains, diarrhea or irritable bowel, testicular or pelvic pain, urinary frequency
or urgency, dysequilibrium, and tremors are also common symptoms.
Some of the dysautonomia symptoms can be disabling.

Rarer symptoms may relate to panniculitis and hepatitis. Rarely as well are
congenital and intrautero infection; when this occurs, it appears
to be similar to toxoplasmosis and rubella, i.e., a primary infection
during the first trimester. The occurrence of optic neuritis or
uveitis raises other possibilities such as multiple sclerosis, but
can be part of Lyme Disease.

The course of the disease can best be described as persistent, but
with periods of worsening symptoms, often cyclical every few weeks
or monthly. Especially disconcerting are persistent symptoms such
as headaches and fatigue that can be exhausting. Some patients are more symptomatic than are others, which may reflect genetically- determined differences in responsiveness or extent of infection.

The disease does not appear to be progressive or destructive, as
with cancer, nor is it fatal, but can be very debilitating.

The incidence of asymptomatic infection has not been adequately
delineated. There appear to be substantial numbers of patients
who remain asymptomatic, but reactivate their disease a number of
months or years later, following trauma, pregnancy, a medical
illness for which an antibiotic is prescribed, or other stresses,
including psychological stresses (9). The Lyme OspA vaccine has
appeared to reactivate Lyme Disease in a number of individuals who
knew, but some who did not know, they had prior Lyme Disease (11).
The mechanisms responsible for the reactivation of the disease
have not been defined, but may include both molecular mimicry and
underlying infection.


The pathogenesis of Lyme Disease remains to be defined. From the
available studies, it would appear that the organisms are trophic
for either the endothelial cells of the blood vessels that serve
the nervous system or for the glial or neural cells themselves
(4,24,26,31). Accumulating evidence supports the hypothesis of
a persistent infection as the cause of the persisting or relapsing
symptoms (26,31). Whether molecular mimicry is involved in the
pathogenesis of some of the symptoms remains more speculative (18).

Although arthritis can occur in Lyme Disease, the organisms can
only rarely be found in synovial tissue. And as many of the
arthralgias that occur in the disease do not respond well to
antiinflammatory agents, the disease is more of an infectious
neuropathy than an actual invasion of synovial or bursal tissues.


The diagnosis rests heavily on the clinical symptomatology.
When there are clinical signs, e.g., rash, aseptic meningitis,
optic neuritis, arthritis, an appropriate differential
diagnosis must be pursued. On a clinical basis, "chronic
fatigue syndrome" or "fibromyalgia" cannot be readily
distinguished from chronic Lyme Disease. Indeed, accumulating
experience suggests that Lyme Disease may be a frequent cause
of fibromyalgia or chronic fatigue (8,12).

Other microbes have been proposed as causative agents of multisymptom disorders that are being termed chronic fatigue and fibromyalgia, especially
more recently recognized mycoplasma species such as M.fermentans
and M.genitalium, but definitive proof of cause and effect has
not yet been established (6, 23).

There has been an attempt to separate "late" Lyme Disease
from "chronic" Lyme Disease, the former being manifested by
objective signs of arthritis or neurological disease (32).
Some have denied the existence of chronic disease, inferring
that these patients suffer from psychiatric disorders; some
have used the term "chronic" to mean post-treatment disease
("post-Lyme"), assuming that the infection has been treated,
and the remaining symptoms are in the same realm as those
patients who have "fibromyalgia" or "chronic fatigue" (27, 30).

These assertions are speculative and remain unproven. That
chronic Lyme Disease actually exists, and is likely the most
common form of the disease, is supported by epidemiologic
studies demonstrating that 30-50-% of treated and untreated
patients go on to develop a multisymptom disorder typical of,
and indistinguishable from, fibromyalgia and chronic fatigue
(1, 28). As with other multisymptom disorders, chronic Lyme
Disease is a clinical syndrome consisting of fatigue,
arthralgias and myalgias,and other nervous system dysfunction(7).

Furthermore, the results of treatment studies appear to support
the hypothesis that persistent infection is responsible for the
chronic symptoms. It is likely that Lyme Disease will serve as
a useful model for other chronic multisymptom disorders. Whether
the pathogenesis of "late" Lyme Disease differs from that of
the chronic form of the disease remains to be established.

Routine laboratory tests are usually normal in Lyme Disease.
The ESR is most often normal, distinguishing it from some of
the inflammatory disorders such as rheumatoid arthritis or
lupus. Culture of the borrelia is possible early in the
disease, usually from biopsies of the erythema migrans rash;
however, most laboratories are not capable of culturing the

The only currently available useful laboratory tests are the
immunologically-based ELISA and Western blot assays. The
recommendation was made in 1994 to have a two-tiered testing
system in which the Western Blot would only be done on ELISA- positive samples (5). The recommendation was based primarily on
the results obtained from patients with arthritis (13), did not
take into account the chronic form of the disease, and was made
despite the lack of consistent reproducibility of results between
various laboratories (2, 16).

The ELISA has been shown to be an unreliable test in many patients with Lyme Disease, both in early infection and later disease (8, 10). Part of the reason for the lack of sensitivity of the ELISA is the use of whole organisms, resulting in a high amount of background absorbance.

After correction for the high background, only a small percentage of
positives can be detected. Because Western blots separate the
proteins of the borrelia, specific reactions can be visualized,
and more accurate interpretations of the results made. Over 75%
of patients with chronic Lyme Disease are negative by ELISA,
while positive by Western blot (8, 10). Patients with
oligoarticular arthritis may be more likely to have robust IgG
responses and positive ELISA tests and IgG Western Blots (13).

By Western blot analyses, the first immunologic reactions in
Lyme Disease are to the 41kd flagellar protein, and the 23kd
OspC protein. Typically, at the time of the ECM rash, there will
be an IgM reaction against the 23kd and 41kd proteins, and no IgG
reactions. Within the next few weeks, the IgM reactions persist,
sometimes accompanied by less specific reactions against 60kd and
66kd proteins, and IgG reactions are now visible against the 23kd
and 41kd proteins. Thus, in the presence of an appropriate
clinical picture, the immunoreactivity against the 23kd and 41kd
proteins appear to be diagnostic of Lyme Disease.

Whereas the 41kd protein is not unique to B. burgdorferi, the 23kd
protein appears to be unique. Also apparently unique proteins of
B.burgdorferi are the 31kd (Osp A) and 34kd (Osp B) outer membrane proteins, and the 35kd, 37kd, 39kd, and 83/93kd proteins. Reactions
to the 31kd proteins are not usually seen until after a year or more following the onset of disease. Not all patients with symptoms for
more than one year, however, display reactions to the outer membrane

Most symptomatic patients have specific reactions on IgM
Western blots (8,10). With resolution of the symptoms, the IgM
reactions disappear or attenuate. IgG reactivity may continue
to be present with resolution of symptoms, but it typically also
disappears or attenuates with successful therapy. There are some
patients (20%) who have symptoms, but whose Western blots are
negative (8,10). If the borrelial organisms remain intracellular,
with no extracellular reemergence once established, this could
explain the absence of additional or persistent immune responses.

PCR (Polymerase Chain Reaction) is a highly sensitive means to
detect microbial DNA or RNA, and it was hoped that this technique
would find an important role in the diagnosis of Lyme Disease.
Thus far, however, despite the specificity of this method,
borrelial DNA or RNA has not been reliably detected in the blood,
urine, or spinal fluid of patients with early or later forms of
Lyme Disease, findings again supportive of an intracellular
reservoir for the borrelia.

It should be possible to develop a better, highly specific ELISA
for Lyme Disease, using recombinant 41kd, 23kd, 31kd and/or 34kd
(and perhaps other B.burgdorferi-specific) proteins. Currently,
however, the Western blot assay is the most reliable immunologic


In vitro, B. burgdorferi is sensitive to several antibiotics
(20,25). This assumption is complicated, however, because of
the long incubation times needed to determine minimum
inhibitory concentrations (MIC), as the borrelia have doubling
times of 20-24 hrs. With these limitations, the results of a
few studies show minimum bactericidal concentrations (MBC) to
penicillin of 8ug/ml, ampicillin: 2ug/ml, tetracycline: 1-2ug/ml,
doxycycline: 2ug/ml, ceftriaxone: 0.5ug/ml, cefotaxime: 0.5ug/ml,
cefuroxime: 1-2ug/ml, cefixime: 8ug/ml,erythromycin: 0.5ug/ml,
clarithromycin: 0.5ug/ml, azithromycin: 0.5ug/ml,
and ciprofloxacin: 4ug/ml.

At the time of the first rash, any one of several antibiotics
appear to be effective, if given for 2 weeks, according to several
published studies. However, a number of patients so treated
developed subsequent symptoms of arthralgias, fatigue, and
paresthesias, with positive Western blots, who were then
successfully treated with longer courses of antibiotics (8, 10).
The recommendation at this time, therefore, is that tetracycline,
doxycycline, or amoxicillin be used for 1 month if ECM is the
only symptom of Lyme Disease.

Once any other symptoms appear, the treatment of Lyme Disease
for only 2-4 weeks is associated with frequent failures and
relapses (8, 10). Our initial experience suggested that a 3 month course of tetracycline was associated with a higher success rate(8).

In patients with symptoms present for more than six months, the
treatment course may need to be more prolonged, or a retreatment
course of varying length may be needed. In patients with symptoms
for more than a year, 12-18 months may be needed for complete resolution of symptoms. The rationale for a longer treatment course is based on extensive observations (8,10), plus the analogy to the longer treatment courses required for tuberculosis, leprosy, Q fever, and certain fungal diseases.

With Lyme Disease, the slow growth rate and metabolic activity of the borrelia would seem to correlate with the need for longer treatment periods.

Once treatment is initiated for patients beyond the earliest
signs of infection, their symptoms frequently increase during
the first several days, or even for the first several weeks of
therapy. For patients with preexisting symptoms of more than a
few months, relief of any of their symptoms may not occur until
after 4-6 weeks of therapy (8, 10). Typically, there are short
periods of relief, followed by relapsing or migrating symptoms;
with continued therapy there are longer symptom-free periods.
Some arthralgias may require 3 months or more to resolve, and
fatigue may be the last symptom to disappear.

The preference for tetracycline evolved because of the large
number of failures that were noted in patients who had been
on ampicillin and doxycycline. Patients generally had some
response to doxycycline, but it was uaually not complete, nor
long-lasting. Tetracycline may be more effective than
doxycycline simply because of the greater dose, i.e., 100mg
of doxycycline twice daily is not equivalent to 500mg of
tetracycline three times daily; also, doxycycline is highly
protein-bound, compared to tetracycline, which could limit the
availability of free drug to diffuse into tissues and cells.

Some physicians use doxycycline at doses of 300-400mg daily to
try to achieve a successful result. A strict comparison
between doxycycline and tetracycline has not yet been
made. Minocycline has also been used by some physicians, with
varying success, but faces the same issues of dosage and
protein binding.

Of the beta lactams used for the treatment of Lyme Disease, the
most efficacious appears to be ceftriaxone. In limited comparitive trials, cefotaxime appears to be equally efficacious, and high-dose
IV penicillin may also be effective.

In early Lyme Disease, oral amoxicillin is as effective as doxycycline. In later disease, many failures are noted, despite the use of up to 3 grams of amoxicillin daily, with probenicid. Cefixime would also not appear to be
effective therapy. Cefuroxime axetil has been evaluated only in
the treatment of early Lyme Disease, and appears comparable to
doxycycline. Limited reports of its use in later Lyme Disease have
not shown it to be efficacious.

The role of the newer macrolides in the treatment of Lyme
Disease needs further assessment. Erythromycin has been regarded
as ineffective, despite its good in vitro sensitivities.
Azithromycin has been reported to be less effective in the
treatment of early Lyme Disease than amoxicillin (21). Some
physicians use clarithromycin and azithromycin in higher dosages
and for longer periods of time, but there have been no reports of
greater success with these drugs than with the tetracyclines or
beta-lactams. In our experience, all macrolides are effective
when combined with a lysosomotropic agent, especially
hydroxychloroquine(see below)(10).

In evaluating the possible factors, it would appear that
antibiotics that can achieve intracellular concentrations and activity are the most efficacious drugs. The results of studies in Klempner's laboratory using a tissue culture model of borrelia infection demonstrated that ceftriaxone was incapable of eradicating intracellular organisms (17); similar experiments in Raoult's laboratory using an endothelial cell model
demonstrated that tetracycline and erythromycin were effective,
but beta lactam antibiotics were not (3). These results are in line with our experience that the tetracyclines and macrolides achieve the greatest success.

In contrast to beta lactams, antibiotics of the tetracycline and macrolide classes are capable of good intracellular penetration. Experience with the macrolide antibiotics has been disappointing, however, when compared with
its in vitro activities against the Lyme borreliae, and with the established efficacy of macrolides against other intracellular parasites such as chlamydia, legionella, mycobacterium-avium intracellulare, and toxoplasma. If, though, the Lyme borreliae reside in intracellular vesicles that are acidic, the macrolides' activity would be sharply decreased at the lower pH.

This is in contrast to the tetracyclines, which are active at acid pH; even
so, the activity of doxycycline was shown to be further increased by increasing the pH. In a tissue culture model of ehrlichia infection, the use of lysosomotropic agents such as amantidine, NH4Cl, and chloroquine increased the killing of intracellular organisms by doxycycline (22).

Based on those studies, and the hypothesis that late Lyme Disease symptoms are due to persisting intracellular infection, we have been successfully treating patients using the combination of a macrolide and hydroxychloroquine (10).

As regards "CNS" disease, there is no evidence that ceftriaxone
is more successful than either the tetracyclines or the combination of macrolide and hydroxychloroquine; if our presumption that the pathogenesis of the disease involves the localization of the borrelia to the endothelial cells of the blood vessels serving the nervous system or to glial or neural
cells is correct, then one would not need to have a drug that can cross the blood-brain barrier to be effective. Indeed, the tetracyclines can cross the blood-brain barrier to some extent, and were used when initially introduced into clinical medicine for the treatment of meningitis, with some success.

Macrolide antibiotics do not cross the blood-brain barrier, but have been
effective in treating other CNS infections (e.g., toxoplasmosis), and in our experience have been effective in reversing the neuropsychiatric symptoms and signs (eg SPECT scans) of Lyme Disease (10). With regard to the issue of bactericidal vs bacteristatic effects, any such effect in vivo has not been demonstrated.

Finally, there have been no reports showing any change in antibiotic resistance patterns during the course of treatment. Ultimately, the determination of efficacy of therapy depends on the clinical response.


The diagnosis and treatment of Lyme Disease have been
hampered by less than adequate diagnostic tests and inadequate
comparisons of antibiotic regimens. Specific antigen-based
ELISA tests should result in greater specificity, but
sensitivity of any tests based on measurements of the host
immune response might still be of limited value if the borrelia
remain intracellular. Most useful would be the development of
tests that can determine the presence and extent of any residual
borreliosis. In the therapy of Lyme Disease, double-blind,
placebo-controlled and comparitive trials are needed to answer
the questions relating to duration and class of antibiotic

The apparent failure of a regimen of one month of
IV ceftriaxone, followed by two months or oral doxycyline,
to improve the outcomes of patients with chronic Lyme Disease
(19) was not surprising, based on prior observations that neither
regimen used for a limited duration was capable of yielding
patient improvement (8,10,33). Additional trials are needed to
evaluate whether longer durations of treatment, using tetracycline
itself, or the novel combination of macrolide and lysosomotropic
agent, would be proven effective treatments.


1. Asch ES, Bujak DI, Weiss M, et al. Lyme Disease: an infectious
and postinfectious syndrome. J Rheum 21:454-61, 1994.

2. Bakken LL, Case KL, Callister SM, et al. Performance of 45
laboratories participating in a proficiency testing program for
Lyme Disease serology. JAMA 268:891-5, 1992.

3. Brouqui P, Bodiga S, and Raoult D. Eucaryotic cells protect
Borrelia burgdorferi from the action of penicillin and ceftriaxone
but not from the action of doxycycline and erythromycin. Antimicrob
Agents Chemother 40:1552-4, 1996.

4. Cadavid D, O'Neill T, Schaefer H, and Pachner AR. Localization of
Borrelia burgdorferi in the nervous system and other organs in a
nonhuman primate model of Lyme disease. Lab Investigation 80:1043-54,

5. Centers for Disease Control. Recommendations for test performance
and interpretation from the Second National Conference on Serologic
Diagnosis of Lyme Disease. MMWR 44:590-1, 1995.

6. Choppa PC, Vojdani A, Tagle C, et al. Multiplex PCR for the
detection of Mycoplasma fermentans, M. hominis, and M. penetrans in
cell cultures and blood samples of patients with chronic fatigue
syndrome. Mol Cell Probes. 12:301-8, 1998.

7. Donta ST. Lyme Disease: A clinical challenge. J Spirochet and
Tick Dis 2:50-51, 1995.

8. Donta ST. Tetracycline therapy of chronic Lyme Disease. Clin
Infect Dis 25: S52-56, 1997.

9. Donta ST: Reactivation of latent Lyme Disease. X Annual LDF
International Conference on Lyme Borreliosis, National Institutes of Health, April 1997.

10.. Donta ST. Treatment of chronic Lyme disease with macrolide
antibiotics. In: Program
and abstracts of the VIIIth International Conference on Lyme
Borreliosis; June 20-24, 1999; Munich, Germany. Abstract P193.

11. Donta ST: Reactivation of Lyme Disease following OspA vaccine.
Int J Antimicrob Agents 17:S116-7, 2001.

12. Donta ST: The existence of chronic Lyme Disease. Current
Treatment Options in Infectious Diseases 3:261-2, 2001.

13. Dressler F, Whalen JA, Reinhardt BN and Steere AC. Western
blotting in the serodiagnosis of Lyme disease. J Infect Dis
167:392-400, 1993.

14. Fallon B and Nields JA. Lyme disease: a neuropsychiatric illness.
Am J Psych 141:1571-83, 1994.

15. Feder HM Jr, Gerber M, and Krause PJ. Early Lyme disease: a
flu-like illness without erythema migrans. Pediatrics 91:456-9, 1993.

16. Fister RD, Weymouth LA, McLaughlin JC, et al. Comparative
evaluation of three products for the detection of Borrelia burgdorferi
antibody in human serum. J Clin Microbiol 37:2834-7, 1989.

17. Georgilis K, Peacocke M, and Klempner MS. Fibroblasts protect
the Lyme Disease spirochete, Borrelia burgdorferi, from ceftriaxone
in vitro. J Infect Dis166:440-4, 1992.

18. Gross DM, Forsthuber T, Tary-Lehman M, et al. Identification of
LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.
Science 281:703-6, 1998.

19. Klempner MS, Hu LT, Evans J, et al. Two controlled trials of
antibiotic treatment in patients with persistent symptoms and a
history of Lyme Disease N Engl J Med. 345: 85-92, 2001.

20. Levin JM, Nelson JA, Segretti J, et al. In vitro susceptibilities
of Borrelia burgdorferi to 11 antimicrobial agents. Antimicrob Agents
Chemother 37:1444-6, 1993.

21. Luft BJ, Dattwyler RJ, Johnson RC, et al. Azithromycin compared
with amoxicillin in the treatment of erythema migrans. A double
blind, randomized, controlled trial. Ann Int Med 124:785-91, 1996.

22. Maurin M, Benoliel AM, Bongrand P, and Raoult D.
Phagolysosomal alkalinization and the bactericidal effect of
antibiotics: the Coxiella burnetii paradigm. J Infect Dis
166:1097-102, 1992.

23. Nicolson GL, and Nicolson NL. Chronic infections as a common
etiology for many patients with chronic fatigue syndrome, fibromyalgia,
and Gulf War Illness. Intern J Med 1:42-6, 1998.

24. Pachner AR, Delaney E, O'Neill T, and Major E. Inoculation of nonhuman primates with the N40 strain of Borrelia burgdorferi leads
to a model of Lyme neuroborreliosis faithful to the human disease.
Neurology 45:165-72, 1995.

25. Preac-Mursic V, Wilske B, Schierz G, et al. In vitro and
in vivo susceptibility of Borrelia burgdorferi. Eur J Clin
Microbiol 6:424-6, 1987.

26. Roberts ED, Bohm RP Jr, Lowrie RC Jr, et al. Pathogenesis
of Lyme neuroborreliosis in the Rhesus monkey: the early
disseminated and chronic phases of disease in the peripheral
nervous system. J Infect Dis 178:722-32, 1998.

27. Seltzer EG, Gerber MA, Carter ML, et al. Long-term outcomes of
persons with Lyme disease. JAMA 283:609-616, 2000.

28. Shadick NA, Phillips CB, Logigian EL, et al. The long-term
clinical outcomes of Lyme Disease. Ann Intern Med 121:560-7, 1994.

29. Steere AC, Malawista SE, Hardin JA, et al. Erythema chronicum
migrans and Lyme arthritis: the enlarging clinical spectrum. Ann
Intern Med 86:685-98, 1977.

30. Steere AC. Lyme Disease. NEJM 345:115-25, 2001.

31. Straubinger RK. PCR-based quantification of Borrelia burgdorferi
organisms in canine tissues over a 500-day postinfection period.
J Clin Microbiology 38:2191-9, 2000.

32. Wormser G, Nadelman RB, Dattwyler RJ, et al. Practice guidelines
for the treatment of Lyme disease. Clin Infect Dis 31(S1):S1-S14, 2001.

33. Ziska MH, Donta ST, and Demarest FC. Physician preferences in
the diagnosis and treatment of Lyme Disease in the U.S. Infection
23:1-5, 1995.

Sam T. Donta, M.D.
Professor of Medicine,

Divisions of Infectious Disease and BioMolecular Medicine Director, Lyme Disease Unit Boston University Medical Center, Boston, Massachusetts

Corresponding author for proof and reprints:

Sam T Donta M.D.

Boston Medical Center

650 Albany Street, 8th floor

Boston MA 02118

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Article Comments Post a Comment

I think this artical is very good
Posted by: cazoome
Jun 23, 2009
this artical is very good
Reply Reply

Late & Chronic Lyme Disease
Posted by: Graham Mustow
Mar 16, 2010
Wow, finally I have some answers, I had Lymes Disease in 1992. My symptoms come and go even now. Excellent, Thank You.


Posted by: racjaa
Jul 23, 2009
excellant article, Lyme disease does not always go away after initial treatment. Many doctors will not even treat patients after initial antibiotics course. It is great to read that studies support increased antibiotic treatment for those who have long term Lyme symptoms
Reply Reply

Best report available
Posted by: ddrsi
Apr 1, 2010
This article could not be any more informative!! Long term symptoms, are right on, and the treatment discussion leaves the reader confident with the knowledge of the options. Anyone with long term symptons, knows how hard it is to describe their experiences to physicians. Thank you for writing this article
Reply Reply

This article is an advocate for Chronic Lyme Patients
Posted by: rosterspot
Apr 26, 2010
Having been recently diagnosed after a year of Lyme symptoms, I hope more patients and doctors find this information. The pathology of Lyme disease is very misunderstood by everyone but this article does a great job of explaining it.
Reply Reply

Posted by: Classique
Jul 11, 2010
My symptoms of Lyme Disease lasted over 18 months before I was diagnosed. Attributing the aches and pains and other problems with getting older. I was diagnosed and was put on a course of tetracycline for 30 days and it relieved my symptoms in the first week. Now though, I have reoccurring problems that I attribute to the Lymes. But going back to a health professional is something that I dread for the very reasons in the article. Will it be the Lyme's Disease? If after tests show a negative to it where does one go from there. Hopefully the medical experts will come up with a more postitive test for this reoccurring problem.
Reply Reply

Lyme Disease and RA
Posted by: Ann-RA
Sep 25, 2010
Very informative and helpful. Was told that my Rheumatoid Arthritis may have been caused by Lyme Disease. Glad to find some information relating to that poosibility and will talk to my rheumatologist about testing me. But will dr agree that there may be a link? Looks like the Western blot assay may be the test to have done? Is there more info about the link between the two diseases?
Reply Reply

Fibromyalgia or Post-Lyme Disease?
Posted by: USAMaid
Oct 16, 2010
Since 1995 I have been treated for fibromyalgia. None of the drugs worked, so I discontinued all four years ago. Coincidentally I had a diverticulitis flare-up and was kept overnight in the ER and put on IV with broad-based antibiotic Unisyn. Amazingly, for two weeks after that IV, I had no pain anywhere in my body. I began to doubt the fibromyalgia at that point. Since pain responded to antibiotics, I began to think Lyme Disease. I am an avid gardener and live adjacent to a wetlands and nature preserve, so deer ticks would certainly be present. A year or so ago, my doctor told me he saw faint Lyme bands in my bloodwork, so what we have here is a missed Lyme diagnosis. I have pain all over my body, cannot sit for more than half an hour without barely being able to walk upon arising, have tinnitus in my left ear, have crawling sensations across my neck and shoulders and have all-over itching at night. I actually keep a natural bristle brush by my bedside and scratch my body before going to bed at night. I own a retail store, so am on my feet six days a week. I've heard about Dr. Donta and would very much like to have him see me. After Christmas I will have more free time and will definitely make an appointment. The article was a treasure trove of information on every level. There is no doubt he knows his subject matter inside and out. I would give anything to be able to power walk again. I can barely walk without pain in my hips and the outsides of my thighs. This article gave me hope for the first time in 15 years.
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Extremely informative
Posted by: Mariette
Nov 5, 2010
Just fabulous. I have been diagnosed with chronic lyme disease as of October 27, 2010 It is a long story which I have started to write. So many years of miss diagnosis,such as fybromyalgia, heart arithmya with no cause, depression because of my extreme fatigue, not counting the series of specialist that came up with nothing. Only one of them validated that something was terribly wrong but just could not diagnose it. How? you may ask did it get diagnosed... by a passing comment of one of my lifelong girl friend. Asked for the test and voila... years later I have hope for my future. This article is the best so far. I have taken notes and will refer to it in my writing. I am working on establishing a blog in order to perhaps help others hope in this voyage that can be lonesome. Humm! you may want to look for words from a teacher such as ¨Sick of being sick¨.
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I was looking for a gift for my friend suffering
Posted by: Matthew_McCabe
Jan 11, 2012
I was looking for a gift for my friend suffering from CFS, and somehow stumbled upon this page with such an extensive collection of medical knowledge. My friend loves hand gels, and I was wondering if anyone knows a particular one that might be good for CFS patients.
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Lyme's article
Posted by: historygenie
Mar 10, 2012
My husband has had this since October 1987, but it took 7 months before we had a diagnois on his medical problem, by chance it was our watching an article on 20/20 back then, we figured out what was wrong.

He is now going through his 4th onslaught of this disease, and I will have to find a specialist in our area to treat him. Since the family doctor who is wonderful, does not grasp the dire medical problems this can and is causing him. It has taught me to be very pro-active on this matter, since so little is known and you have to become your own researcher if you want the medical facts.

This article proves what we all have been telling the medical community, this disease does not come with simple instructions you have to listen and learn. Thank you Dr. Sam Donta.
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Posted by: jesseharr
May 10, 2012
Does anyone know the affects of lymes antibiotics have on the lymes testing. I have been sick for 3 yrs (Fatigue dizzyness,brain fog,trouble sleeping, achey all over, chest pain, no strenght) and am certain its lymes but tested negative. Iv been tested for everything else and my bloodwork always comes back excellent. I was on lyme antibiotics a month before i got tested for lymes could that affect the results? Also every spring and summer i am overcome with extreme fatigue much worse then fall and winter does that sound like something lymes does.


Posted by: jesseharr
May 10, 2012
Does anyone know the affects of lymes antibiotics have on the lymes testing. I have been sick for 3 yrs (Fatigue dizzyness,brain fog,trouble sleeping, achey all over, chest pain, no strenght) and am certain its lymes but tested negative. Iv been tested for everything else and my bloodwork always comes back excellent. I was on lyme antibiotics a month before i got tested for lymes could that affect the results? Also every spring and summer i am overcome with extreme fatigue much worse then fall and winter does that sound like something lymes does.
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Some support
Posted by: JeffP.
Aug 30, 2012
The tests for lyme are not reliable. You sound like you have lyme disease. Most MDs are not fully equipped to treat or even understand the disease. Antibiotics would affect your tests as the spirochete would change form in your body and become undectable. It has 3 forms and once treated the spirochete hides in the body. So your lyme results would come back negative. You need to find a lyme literate doctor and push your way into prolonged(Months of) antibiotic treatment. 2 weeks does something... but not enough. Stay strong. There's light at the end of the tunnel.


Posted by: crowb1kanobe
Oct 12, 2015
You will have to use Igenex Lab in California to get accurate testing. They do extensive testing. Unfortunately, they do not bill insurance. If you have an out of network coverage then a portion would be able to be submitted. For the Lyme, Bartonella and Babesiosis its about 1459.00. I know this because my lyme doctor just ordered them and I am going to have to pay out of pocket for them. You can find many sites with people telling you to use them. Also you can contact ILADS and they can find lyme specialists in your area. That's how I found mine. I waisted 6 weeks of very critical time on going to MDs and internal med docs. I am also a nurse and this disease has turned my life into a living nightmare. I listen to Eckhart Tolle on youtube as he is an uplifting speaker. He wrote the book In the Now. ILADS specialists are trained extensively on all the bacteria, suppliments, treatment , life stages of bacteria, co infections, etc... Be well


Lyme disease undiagnosed
Posted by: LymeDizease
Jun 18, 2012
I had Bells Palsy 3 times. 1990 I had it and it was idiopathic (no idea what caused it) 2nd time a couple years later, saw neurologists , and still ideopathic. After the 3rd time, there was enough written about Lyme Disease that my family physician put it together, and said the BP was a result of the Lyme. Top Drs checked me and said I have all the symptoms of Lyme, but no positive test results, but they are calling it Lyme Disease, if it walks like a duck, and quacks like a duck, then its a duck. Here it is 22 years later, and I still feel like shit, am stiff, swollen, and arthritic.. This aint no fun.
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Lyme Disease - Ehler Danlos Syndrome
Posted by: StephGorsuch
Sep 1, 2012
Has there ever been a study on the correlation between Lyme disease and Ehler Danlos Syndrome patients?
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Posted by: rg02
Nov 29, 2012
Lyme is a spirochete. Syphilis is a spirochete. Why is Lyme not treated in a prophylactic manner as is syphilis. Same symptoms, same progression to include latent periods.

Never had Lyme myself but had recurring tick fever(1972) in line with Rocky Mountain spotted fever. Diagnosed only after several months and several physicians. Cardiologist told me to get prophylactic antibiotics for any tick bite as I would now have limited resistance and disease could progress while never demonstrating a rash. This was an easy request from any physician until ~10yrs ago when physicians began to refuse as I did not present with " bulls-eye" rash. I get the deer-in-headlights look when I say Rocky Mountain doesn't have a bulls-eye rash.

What has changed in medical thinking?
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Excellent article!
Posted by: richcarson
Dec 14, 2012
I am impressed with the excellent article.
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43 years of Lyme
Posted by: Granny2Shoes
Apr 21, 2013
Dr. Donta diagnosed me at 30 years after being sent to him by an acupunturist. My crazy history, plus brain sprct scan, were convincing. My scan belonged in a textbook, he said, the perfet picture of 30 years of Lyme.
As an RN I wondered while so many die within months what do some of us have in our genes that we can live so long. Dr. Donta said he had patients over 40 yrs with it, and here I am. I'm in RI where I began, where docs still think I have fibromyalgia and chronic fatigue.
I wish I could donate my brain to Lyme research. ~Granny2S.
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Posted by: MickeyMousey
May 14, 2014
I have been suffering for five years from Lyme Disease type symptoms. I go through periods of remission & as the years have progressed my symptoms seem to have got slightly milder which is great. However, the initial onset of symptoms were incredibly severe causing collapse & admission to hospital, (symptoms included severe disorientation, complete & utter fatigue, flu like illness, muscle pain in legs & knee joints, sometimes being unable to stand).
I was given just about every test, (not for Lyme), & all was negative. Two years after the onset of the initial illness & after several chronic relapses l insisted on being tested for Lyme. This came back negative.
Six months before the illness started l was on a walking holiday in rural France. We were in a forest that had some deer & l remembered l got bitten on the back of the leg. I thought it must have been a large horse fly as there was a lot of blood from the spot of the bite. My husband remembered that the site of the bite produced a round bullseye type of rash, (l had forgotten this). My illness symptoms did not start until six months after this incident. Can there be a six month delay from an initial bite to first symptoms?? I would be grateful if you could let me know.
Some Doctors in Britain do not know enough about Lyme Disease or even recognise it as something that effects this country so it is very hard to get a definitive diagnosis over here which is very frustrating. Over time l have learnt to deal with the relapses as they occur & except it as something l have as fighting it makes you feel a lot worse.
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Posted by: crowb1kanobe
Oct 12, 2015
Contact ILADS they can find you a lyme specialist. I know British Columbia has them. Hope you are well.


in need of help..
Posted by: tickbit
Dec 28, 2014
I am a male at 44yrs of age. I am an avid outdoorsman who was bitten on my neck over a year ago by a tick. My first symptoms started as blurred and double vision, followed by confusion, brain fog and short term memory issues. Then came severe fatigue, weakness, shortness of breath. blood in urine, enlarged heart with pains in chest and ribs. Now my arthritic symptoms are extreme throughout whole body. My fingers and knees, elbows, and ankles and toes will actually lock up at times. I now have glasses as my vision became so poor. At times can hardly catch my breath.About one month ago i literally thought i might die from this. I need to see a Dr who can help prove i am fighting Late stage or Chronic Lyme Disease. I am also experiencing pain in my temple areas of my skull that radiates upward, an and MRI proved it has damaged my brain. Uncontrollable itching at night, shooting pains throughout body,frequent urinating, loss of 20lbs in 6 week period of onset of these symptoms. really to many to list. I live in Northern Michigan and am fighting like crazy to cope with it. Can anyone help ????
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In need of help
Posted by: crowb1kanobe
Oct 12, 2015 must get an ILADS doctor. They will find then in two days time. Your symptoms are severe and you need to seek an lyme specialist asap. I hope you are ok. I am an RN and have been infected myself. I used them and I am so happy to have my doc. I feel like crap but I know im good hands. They are specifically trained in lyme. Igenex lab in CA is who you need to get adequate testing from. Take care


Lyme disease
Posted by: LymeDiseaseEditor
Dec 29, 2014
Hi tickbit -
I am so sorry for your poor health. I have chronic Lyme disease and have experienced what you describe and it is horrible and frightening. You are not alone.
First you need to find a Lyme-literate doctor in your area. The Michigan Lyme Association should be able to help you find a good one. The only reliable test for diagnosing Lyme is a blood culture by Advanced Lab Services in PA - it must be ordered by a doctor and you have to pay for it yourself but it will be verified by DNA so you won't be guessing. The western blot and ELISA assay tests lose up to 50% of positive test results due to lack of antibodies or lack of sensitivity - especially in chronic cases. Once you have a diagnosis, the treatment is long - a direct ratio to how long you have been infected. Antibiotics have the best results for full recovery but again, if you have been sick for a long time you need large doses of antibiotics according to lyme experts. You can get a free copy of Dr. J. Burrascano's Lyme disease Treatment Guidelines. Google that and you will find many free download sites.

Prohealth will soon be covering Lyme disease with new products and resources to help. As the Lyme editor I am happy to help in any way I can.

Be well,

Jenna Seaver
Prohealth Lyme Writer and Editor
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I became infected in early 80's after tetracycline had a relasp and pretreatment
Posted by: jackcornwell
Feb 8, 2015
I am a long term Lyme patient, 30 plus years. Undiagnosed do 9 mo. And relapsed later with more tetracycline. After that my life changed long term.
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chronic recurring chest pain
Posted by: nedmedic
Oct 1, 2015
I was originally diagnosed with Lyme in 1991 after ending up in CCU for chest pains. The determination was Peri-Myocarditis 2nd to Lyme disease. I received 30 days intravenous Antibiotic. and symptoms abated but they return approximately every other month and I have continual chest pain that is at about a level 3 ( all the time) but can get as high as 7-10 when I am stressed.
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No overlap with Chronic Fatigue Syndrome
Posted by: enna1921
Oct 30, 2015
There is a difference between chronic fatigue and Chronic Fatigue Syndrome. The defining characteristic of CFS is post-exertional malaise. There are also many other symptoms that have nothing in common with Lyme Disease. Read the International Consensus Criteria on CFS/ME for the complete list. You dismissed CFS in the same way that some medical professionals dismiss Lyme Disease. Do better research before you make claims of overlap.
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