ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

AMA journal associates iron deficiency with hearing loss

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

NIH News: New Compound That Acts on Peripheral Receptors May Be Promising Treatment for Some Nerve Pain

  [ 319 votes ]   [ 1 Comment ]
www.ProHealth.com • August 11, 2003


NATIONAL INSTITUTES OF HEALTH:  NIH News

Results of a new study in mice and rats show that a compound which acts on a specific type of cell receptor found only outside the central nervous system decreases the animals' pain responses. But the researchers caution that studies investigating the safety and efficacy of this compound in humans have yet to be done.

The scientists hope this approach may lead to the development of pain-relief drugs that lack the debilitating central nervous system side effects limiting the effectiveness of currently available pharmaceuticals.

"Chronic pain is one of the most significant disease states affecting Americans, in terms of economic and social impacts," says Dr. Nora D. Volkow, Director of the National Institute on Drug Abuse. "And, unfortunately, therapeutic options for the treatment of chronic pain are inadequate, partly because a number of drugs that can be used to treat pain have unpleasant side effects that limit their effectiveness, and partly because some of them have the potential for addiction and abuse."

The study, funded by NIDA, part of the National Institutes of Health, will be published online the week of August 11 in the "Proceedings of the National Academy of Sciences".

Dr. T. Philip Malan, Jr., of the University of Arizona, Dr. Alexandros Makriyannis, of the University of Connecticut, and their colleagues, studied the activity of a new compound called AM1241, which acts on CB2 cannabinoid receptors. "This is one of the two types of receptors on which THC, the active ingredient in marijuana, acts," Dr. Malan says. "The CB2 receptors are in peripheral sites with immune functions, while the CB1 receptors are in the central nervous system -- the brain and spinal cord. The beauty of having a compound that acts on the CB2 receptors is that you can get pain relief without the central nervous system side effects of THC, such as sleepiness and anxiety."

The scientists tested the chemical on mice and rats with neuropathic pain, a complex chronic pain state resulting from nerve injury or disease. They found that this compound increased the ability of the animals to withstand chronic pain that mirrored human models of neuropathic pain.

"Although this is far from being in clinical trials in humans, any new avenue to treat pain is a very positive step," Dr. Malan says. "Almost 6 million people in the United States may experience neuropathic pain. At almost any given time, about 1 person in 4 is experiencing some type of pain and about 1 person in 8 has some type of chronic pain. Pain costs the U.S. economy $120 billion to $180 billion per year. Even though we have therapies, many people continue to experience pain despite receiving treatment. This may be partly because the side effects of many of the drugs we can use prevent patients from using the dose that provides the most intense relief."

The next step, he says, is to test this compound in animals to assess its potential toxicity. "We don't even know how it works. It may act on peripheral nerves, but CB2 receptors have not yet been found there; it may act in some way to inhibit the release of chemicals like prostaglandins from immune cells that increase sensitivity to pain; or they may cause immune system cells to release substances that block the pain response."

AM 1241 was developed by Dr. Makriyannis.

The National Institute on Drug Abuse is a component of the National Institutes of Health, U.S. Department of Health and Human Services.

NIDA supports more than 85 percent of the world's research on the health aspects of drug abuse and addiction. The Institute carries out a large variety of programs to ensure the rapid dissemination of research information and its implementation in policy and practice. Fact sheets on the health effects of drugs of abuse and information on NIDA research and other activities can be found on the NIDA home page at http://www.drugabuse.gov.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

New Compound
Posted by: ida01
Oct 11, 2007
This would be nice, but it'll take years before we humans get to try it. The compound I use is Baclofen/Lidocaine/Ibuprofen. I find it helpfull. I have a torn rotator cuff that cannot be fixed. The pain across my neck, shoulder, down my arm is off the charts. So I use tis compound and meds of course. It's worth a try. Ida01
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map