Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

'Healthy' Foods Differ by Individual

Higher vitamin D levels may be protective against acute rhinosinusitis

Curcumin: The All In One Solution

Eating More Homemade Meals May Reduce Risk of Type 2 Diabetes

Vitamin D Supplementation Associated with Improved Exercise Performance

Saffron reduces oxidative stress in metabolic syndrome patients

Specific vitamin D levels linked to heart problems

Basic Vitamin A Primer

Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control r...

Print Page
Email Article

Many FM & ME/CFS patients in D-ribose study report quality of life improvements

  [ 1379 votes ]   [ 2 Comments ] • December 6, 2008

The natural dietary supplement D-ribose - a form of sugar essential to fuel cellular energy generation - "significantly reduced clinical symptoms in patients suffering from Fibromyalgia and Chronic Fatigue Syndrome," a Texas-based research group reported.

Their study - "The Use of D-Ribose in Chronic Fatigue Syndrome and Fibromyalgia" - headed by internationally recognized FM/CFS Doctor Jacob Teitelbaum, MD, was published in the November 2006 issue of the Journal of Alternative and Complementary Medicine.*

Key Findings

Of 41 study participants diagnosed with ME/CFS and/or FM who received D-ribose supplementation daily for four weeks, 66 percent achieved “significant improvements in quality of life," the report states. Change was measured using patients' before-and-after visual analog scale (VAS) scores for energy, sleep, mental clarity, pain intensity, and well-being, as well as global quality of life assessments.

Key findings for the patients who perceived significant change included:

• 45 percent average improvement in energy score

• 30 percent average improvement in overall well-being

These findings are considered statistically significant (P < 0.0001), meaning the probability they were owing to chance is less than 1 in 1,000. In particular, the report indicates, patients tended to perceive improved "ability to overcome fatigue," as well as less muscle soreness and stiffness. And supplementation with the natural substance D-ribose was "tolerated well."

Study Details

The study was open label and uncontrolled, meaning all participants took D-ribose, no patients were given a placebo, or "fake" dose as a means of comparison, and no subjects with normal health were included as a means of comparison. Termed a "feasibility" study, the research involved a small number of patients, as a possible preliminary to more extensive investigation. Of the 41 patients, 78 percent were female and their average age was 48. They took five grams of D-ribose by mouth three times a day for an average of 28 days.

What is D-ribose?

D-ribose, also called “ribose,” is a form of sugar containing five carbon atoms that all living cells require for creation of ATP (adenosine triphosphate), the body's main source of energy. D-ribose is also a crucial component of other important molecules within our cells, such as RNA (ribonucleic acid), and DNA (deoxynbonucleic acid). DNA produces the proteins cells need to function and develop, while RNA provides the instructions for the job.

How is D-ribose Obtained?

Our bodies make D-ribose for use by the cells from glucose - a sugar that contains six carbon atoms, which plants manufacture by the process of photosynthesis. We obtain glucose, also known as "blood sugar," from the fruits, berries, vegetables, and honey we eat. In a glucose-deficient pinch - such as starvation, fasting, or extremely demanding exercise - our liver and even our kidneys may also synthesize glucose from other compounds to provide a source of D-ribose for the cells. But this is an energy-intensive process.

D-ribose has also long been available as a dietary supplement, produced by fermentation of corn syrup. And it can be obtained from some RNA-rich food substances such as brewer's yeast.

What's the Theory of Benefit?

How do the researchers think D-ribose supplementation supports improved ME/CFS and FM patient quality of life? Many scientists have come to believe that "inefficient" or "disordered" cellular metabolism may account for the symptoms of fatigue and muscle pain associated with ME/CFS and FM.

Patients' muscles become "anaerobic" or depleted of oxygen faster than the muscles of normal healthy people. And supplementation with the nutrient D-ribose may represent one avenue for supporting faster regeneration of ATP and healthier metabolism in oxygen-deprived muscle cells.


* To review an abstract of the study report, go to

Note: This information has not been evaluated by the FDA. It is not meant to diagnose, treat, cure, or prevent any illness, disease, or condition. It is very important that you never make any change in your health support plan or regimen without reviewing and discussing it collaboratively with your professional healthcare team.

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Posted by: jweismann
Dec 6, 2006
i found this article most interesting, as i tried D-ribose as a powdered supplement about 2 years ago & really felt it helped w/energy & muscles not getting so fatigued, but was unable to afford to continue it's use. Although caffiene is a big fibro trigger for me, i occasionally need it anyway! i discovered the energy drink MDX made by Mountain Dew contains D-ribose and it is the ONLY one that not only does not make me jittery at all, but it also does not trigger fibro symptoms, nor keep nme awake. I only use it a few times a month, so perhaps regular use would aggravate things due to the caffiene, but i'm very pleased thus far!! as an aside, i have been almost symptom free for 18 months by using a sudafed/guafenisen/dextromethorthan (sp??) cold tablet every day....not exactly following the protocol recommended on this site, but after 17 years since diagnosis, i'm thrilled & pretty convinced this is why.
Reply Reply

D-ribose and hypoglycemia
Posted by: meditationlotus
Dec 17, 2006
How does d-ribose work if you have hypoglycemia? I have hypoglycemia and tried d-ribose, and it seems like i felt worse, but you never know for sure what is causing a symptom. Is there any info about taking d-ribose if you have hypoglycemia? I emailed about it, but no one responded.


Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing