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Oxidative stress and mitochondrial dysfunction in Fibromyalgia: Minireview – Source: Neuro Endocrinology Letters, Apr 29, 2010

  [ 50 votes ]   [ 2 Comments ]
By MD Cordero, et al. • • May 6, 2010

Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and pathophysiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of FM. Furthermore, it is controversial the role of mitochondria in the oxidant imbalance documented in FM.

Signs and symptoms associated with muscular alteration and mitochondrial dysfunction, including oxidative stress, have been observed in patients with FM.

In this respect, Coenzyme Q-10 (CoQ-10) deficiency, an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant, alters mitochondria function and mitochondrial respiratory complexes organization and leading to increased ROS generation [ROS = reactive oxygen species, which at high levels can result in significant damage to cell structures, the situation known as oxidative stress].

Recently has been shown CoQ-10 deficiency in blood mononuclear cells in FM patients, so if the hypothesis that mitochondrial dysfunction is the origin of oxidative stress in FM patients is demonstrated, could help to understand the complex pathophysiology of this disorder and may lead to development of new therapeutic strategies for prevention and treatment of this disease.

Source: Neuro Endocrinlogy Letters, Apr 29, 2010; 31(2):169-173. Cordero MD, Miguel MD, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM. Department of Normal and Pathological Citology & Histology, Faculty of Medicine, University of Seville, Seville, Spain. [Email:]

Please Discuss This Article:   Post a Comment 

Mitochondrial dysfunction and Substance P
Posted by: IanH
May 7, 2010
In addition or alternatively, perhaps, we know that elevated sP interferes with oxidative phosphorylation and substance P is elevated in Fibromyalgia.
Reply Reply

any relationship between CoQ 10 and substance P
Posted by: IanH
May 7, 2010
Is there any relationship between CoQ10 deficiency and substance P or any of the other neurokinins?


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