Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and pathophysiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of FM. Furthermore, it is controversial the role of mitochondria in the oxidant imbalance documented in FM.
Signs and symptoms associated with muscular alteration and mitochondrial dysfunction, including oxidative stress, have been observed in patients with FM.
In this respect, Coenzyme Q-10 (CoQ-10) deficiency, an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant, alters mitochondria function and mitochondrial respiratory complexes organization and leading to increased ROS generation [ROS = reactive oxygen species, which at high levels can result in significant damage to cell structures, the situation known as oxidative stress].
Recently has been shown CoQ-10 deficiency in blood mononuclear cells in FM patients, so if the hypothesis that mitochondrial dysfunction is the origin of oxidative stress in FM patients is demonstrated, could help to understand the complex pathophysiology of this disorder and may lead to development of new therapeutic strategies for prevention and treatment of this disease.
Source: Neuro Endocrinlogy Letters, Apr 29, 2010; 31(2):169-173. Cordero MD, Miguel MD, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM. Department of Normal and Pathological Citology & Histology, Faculty of Medicine, University of Seville, Seville, Spain. [Email: firstname.lastname@example.org]