ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Oxidative stress and mitochondrial dysfunction in Fibromyalgia: Minireview – Source: Neuro Endocrinology Letters, Apr 29, 2010

  [ 50 votes ]   [ 2 Comments ]
By MD Cordero, et al. • www.ProHealth.com • May 6, 2010

previous article next article

Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and pathophysiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of FM. Furthermore, it is controversial the role of mitochondria in the oxidant imbalance documented in FM.

Signs and symptoms associated with muscular alteration and mitochondrial dysfunction, including oxidative stress, have been observed in patients with FM.

In this respect, Coenzyme Q-10 (CoQ-10) deficiency, an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant, alters mitochondria function and mitochondrial respiratory complexes organization and leading to increased ROS generation [ROS = reactive oxygen species, which at high levels can result in significant damage to cell structures, the situation known as oxidative stress].

Recently has been shown CoQ-10 deficiency in blood mononuclear cells in FM patients, so if the hypothesis that mitochondrial dysfunction is the origin of oxidative stress in FM patients is demonstrated, could help to understand the complex pathophysiology of this disorder and may lead to development of new therapeutic strategies for prevention and treatment of this disease.

Source: Neuro Endocrinlogy Letters, Apr 29, 2010; 31(2):169-173. Cordero MD, Miguel MD, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM. Department of Normal and Pathological Citology & Histology, Faculty of Medicine, University of Seville, Seville, Spain. [Email: mdcormor@upo.es]



previous article
  Rating 3.3 (50 votes) next article




DISCUSS THIS ARTICLE   (2 existing comments) Post a Comment 


Mitochondrial dysfunction and Substance P
Posted by: IanH
May 7, 2010
In addition or alternatively, perhaps, we know that elevated sP interferes with oxidative phosphorylation and substance P is elevated in Fibromyalgia.
Reply Reply

 
any relationship between CoQ 10 and substance P
Posted by: IanH
May 7, 2010
Is there any relationship between CoQ10 deficiency and substance P or any of the other neurokinins?

 

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing