by Source: Cannon JG, Angel JB, Abad LW, O'Grady J, L
January 1, 1999
A study of hormonal response to exercise in female CFS patients found abnormal responses by some measures and normal responses by other measures.
The study was conducted through the CFS Cooperative Research Center in Boston, and involved eight CFS patients in each phase of the menstrual cycle who were matched against eight luteal-phase controls and seven follicular-phase controls. The study found no differences between patients and controls when measuring changes in post-exercise counts of circulating neutrophil, lactoferrin, plasma C3a des arg and creatine kinase. However, differences were seen in relationships between basal neutrophil counts and plasma progesterone concentrations, and between exercise-induced neutrophilia correlated and both urinary cortisol and plasma creatine kinase.
The researchers made the following conclusions:
Contrary to the original hypothesis of this investigation, CFS patients did not exhibit greater systemic manifestations of an inflammatory response than healthy women as defined by the parameters evaluated in this study, i.e., neutrophil mobilization and activation, complement activation, and plasma creatine kinase activity. However, previously described endocrine relationships with the circulating neutrophil pool were observed in the control group but were absent in the patients.
They further concluded that the study provided "additional evidence that CFS patients can be differentiated from healthy individuals by objective physiological and immunological measurements." See the following:
Cannon JG, Angel JB, Abad LW, O'Grady J, Lundgren N, Fagioli L, Komaroff AL. Hormonal influences on stress-induced neutrophil mobilization in health and chronic fatigue syndrome. J Clin Immunol. 1998 Jul; 18(4):291-298.
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