ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

Let Sweet Basil Oil Boost Your Health Today

Print Page
Email Article

Study Shows Paroxetine (Paxil) Reduces Symptoms of Fibromyalgia

  [ 367 votes ]   [ Discuss This Article ] • May 4, 2004

Paxil CR May Offer Help for the Millions of Americans With the Chronic Disorder NEW YORK, May 4 /PRNewswire-FirstCall/ -- GlaxoSmithKline's (NYSE: GSK) Paxil CR(R) (paroxetine HCl)

Controlled-Release Tablets are associated with a significant reduction in symptoms and are generally well-tolerated in fibromyalgia patients, according to results from a new placebo-controlled trial released today. The study, presented at the 157th annual meeting of the American Psychiatric Association (APA) in New York, is the first to look at the benefits of Paxil CR in fibromyalgia -- a chronic disorder for which there is no FDA-approved treatment.

"Fibromyalgia can be an extremely debilitating illness. Unfortunately, with no known cure or well-studied treatments, sufferers are often left to manage their symptoms with a trial-and-error approach," said Prakash Masand, M.D., a study investigator and consulting professor of psychiatry at Duke University School of Medicine. "The results of this study are encouraging because they provide clinical trial evidence that controlled-release paroxetine may reduce the symptoms of fibromyalgia."

Fibromyalgia is a chronic illness characterized by widespread musculoskeletal aches, pain and stiffness, soft tissue tenderness, general fatigue and sleep disturbances. The most common sites of pain (called "tender points") include the neck, back, shoulders, pelvic girdle, hands, knees, elbows and hip joints, but any body part can be involved. Patients experience physical and emotional symptoms that come and go over time. Fibromyalgia affects more women than men and is seen in all age groups, although in most patients, the illness generally begins during their 20s or 30s.

Controlled-Release Paroxetine Superior to Placebo
In a 12-week randomized, placebo-controlled, double blind study of 180 patients with a diagnosis of fibromyalgia, 116 patients were randomized to receive either controlled-release paroxetine, with a dose ranging from 12.5 mg to 62.5 mg daily or placebo. The mean dose given was 39.1 mg. The primary efficacy measure was a 25 percent or greater reduction in scores on the Fibromyalgia Impact Questionnaire (FIQ) from randomization to end of treatment and included the Clinical Global Impression (CGI)-Improvement (I) and Severity (S) measures and the Visual Analogue Scale (VAS) for pain. Data was analyzed using Intent to Treat (ITT) with Last Observation Carried Forward (LOCF) and Kaplan Meier survival models. The study demonstrated that significantly more patients in the controlled-release paroxetine group (57 percent) responded to treatment as shown by a reduction of at least 25 percent on the FIQ, superior to placebo (33 percent) over the 12-week study. Likewise, patients receiving controlled-release paroxetine were more likely to have CGI-I scores of 1 or 2 (much improved or very much improved) (58 percent) compared to patients on placebo (25 percent). There was no significant difference between the controlled-release paroxetine and placebo groups on the VAS pain scores. In this study, side effects were generally mild, with drowsiness (26 versus 6 percent), dry mouth (36 versus 9 percent) and female genital disorder (8 versus 2 percent) reported more frequently in the controlled-release paroxetine group.

Controlled-Release Paxil CR Tablets
Paxil CR(R) (paroxetine HCl) Controlled-Release Tablets offers the proven efficacy of paroxetine in a Geomatrix oral drug delivery system. The tablet is a multi-layered formulation that controls dissolution and allows absorption of the drug further down in the small intestine. Paxil CR offers flexible dosing with three dosing strengths: 12.5 mg, 25 mg, and 37.5 mg. Geomatrix technology is licensed from SkyePharma PLC (Nasdaq: SKYE; LSE: SKP). Paxil CR is currently approved for the treatment of depression, panic disorder, premenstrual dysphoric disorder (PMDD) and social anxiety disorder. Most common adverse events (incidence of 5 percent or greater incidence for Paxil CR and at least twice that for placebo) in studies for major depressive disorder, panic disorder, PMDD and social anxiety disorder include infection, trauma, nausea, diarrhea, dry mouth, constipation, decreased appetite, somnolence, dizziness, decreased libido, tremor, yawning, sweating, abnormal vision, asthenia, insomnia, abnormal ejaculation, female genital disorders and impotence. Patients should not be abruptly discontinued from antidepressant medication, including Paxil CR. Concomitant use of Paxil CR in patients taking monoamine oxidase inhibitors (MAOIs) or thioridazine is contraindicated.

For more information on Paxil CR log on to, or for patients who are being treated with Paxil CR, visit

About GlaxoSmithKline GlaxoSmithKline -- one of the world's leading research-based pharmaceutical and healthcare companies -- is committed to improving the quality of human life by enabling people to do more, feel better and live longer. Company information line: 1-888-825-5249. Web site address: SOURCE: GlaxoSmithKline Web Site:

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map