ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Lilac Oil: More Than Just for Fragrance

Eat More Yogurt and Avoid Osteoporosis

What Is Bilberry Good For?

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Higher omega 3 levels linked to improved brain blood flow

Curcumin, resveratrol, ursolic acid show promise against prostate cancer

Olive oil compound could help protect against brain cancer

 
Print Page
Email Article

Seven genomic subtypes of Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME): A detailed analysis of gene networks and clinical phenotypes – Source: Journal of Clinical Pathology, Dec 5, 2007

  [ 204 votes ]   [ Discuss This Article ]
By Jonathan R Kerr, MD, PhD, et al. • www.ProHealth.com • December 7, 2007


Chronic Fatigue Syndrome / myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. We have recently reported a study of gene expression which identified differential expression of 88 human genes in patients with CFS/ME.

Clustering of QPCR data from CFS/ME patients revealed 7 distinct subtypes with distinct differences in SF-36 scores, clinical phenotypes and severity.

In this study, for each CFS/ME subtype, we determined those genes whose expression differed significantly from that of normal blood donors, and then determined gene interactions, disease associations and molecular and cellular functions of those gene sets. Genomic analysis was then related to clinical data for each CFS/ME subtype.

Genomic analysis revealed some common (neurological, cancer, immunological, inflammatory, hematological) and some distinct (metabolic, endocrine, dermatological, cardiovascular, connective tissue) disease associations among the subtypes.

Subtypes 1, 2 and 7 were the most severe, and subtype 3 was the mildest.

Clinical features of each subtype were as follows:

  • Subtype 1 (cognitive, musculoskeletal, sleep, anxiety / depression);
  • Subtype 2 (musculoskeletal, pain, anxiety / depression);
  • Subtype 3 (mild);
  • Subtype 4 (cognitive);
  • Subtype 5 (musculoskeletal, gastrointestinal);
  • Subtype 6 (postexertional);
  • Subtype 7 (pain, infectious, musculoskeletal, sleep, neurological, gastrointestinal, neurocognitive, anxiety / depression).
  • It is particularly interesting that in these genomically derived subtypes, there were distinct clinical syndromes and that those which were most severe were also those with anxiety / depression, as would be expected in a disease with a biological basis.

    [Note: Dr. Kerr published another article in the same issue titled "Enterovirus infection of the stomach in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)"]

    Source: Journal of Clinical Pathology. Dec 5, 2007. [E-pub ahead of print]. PMID: 18057078, by Kerr J, Burke B, Petty R, Gough J, Fear D, David M, Axford J, Dalgleish A, Nutt D. St George's University of London; King's College London; Sheffield Rheumatology Centre; University of Bristol, UK. [E-mail: jkerr@sgul.ac.uk]





    Post a Comment

    Featured Products From the ProHealth Store
    Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Ultra ATP+, Double Strength

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    NAD+ Ignite with Niagen

    Featured Products

    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils

    Natural Remedies

    Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
    Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
    Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
    Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
    How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map