Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Social Anxiety Disorder Linked to High Serotonin Levels, Throwing Treatment with SSRIs into Serious ...

A short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream surviva...

Therapeutic Effects and Mechanisms of Action of Rifaximin in Gastrointestinal Diseases

Promoting Optimal Nutrition with Digestive Enzymes

Immune response to a flu vaccine yields new insights into narcolepsy

Omega-3 supplements and antioxidants may help with preclinical Alzheimer's disease

Children with Lyme Disease

Health Benefits of Ginseng

7-Keto DHEA The Fat-Burning Metabolite of DHEA

Intestinal Pseudoobstruction Caused by Chronic Lyme Neuroborreliosis. A Case Report

 
Print Page
Email Article

Seven genomic subtypes of Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME): A detailed analysis of gene networks and clinical phenotypes – Source: Journal of Clinical Pathology, Dec 5, 2007

  [ 204 votes ]   [ Discuss This Article ]
By Jonathan R Kerr, MD, PhD, et al. • www.ProHealth.com • December 7, 2007


Chronic Fatigue Syndrome / myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. We have recently reported a study of gene expression which identified differential expression of 88 human genes in patients with CFS/ME.

Clustering of QPCR data from CFS/ME patients revealed 7 distinct subtypes with distinct differences in SF-36 scores, clinical phenotypes and severity.

In this study, for each CFS/ME subtype, we determined those genes whose expression differed significantly from that of normal blood donors, and then determined gene interactions, disease associations and molecular and cellular functions of those gene sets. Genomic analysis was then related to clinical data for each CFS/ME subtype.

Genomic analysis revealed some common (neurological, cancer, immunological, inflammatory, hematological) and some distinct (metabolic, endocrine, dermatological, cardiovascular, connective tissue) disease associations among the subtypes.

Subtypes 1, 2 and 7 were the most severe, and subtype 3 was the mildest.

Clinical features of each subtype were as follows:

  • Subtype 1 (cognitive, musculoskeletal, sleep, anxiety / depression);
  • Subtype 2 (musculoskeletal, pain, anxiety / depression);
  • Subtype 3 (mild);
  • Subtype 4 (cognitive);
  • Subtype 5 (musculoskeletal, gastrointestinal);
  • Subtype 6 (postexertional);
  • Subtype 7 (pain, infectious, musculoskeletal, sleep, neurological, gastrointestinal, neurocognitive, anxiety / depression).
  • It is particularly interesting that in these genomically derived subtypes, there were distinct clinical syndromes and that those which were most severe were also those with anxiety / depression, as would be expected in a disease with a biological basis.

    [Note: Dr. Kerr published another article in the same issue titled "Enterovirus infection of the stomach in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)"]

    Source: Journal of Clinical Pathology. Dec 5, 2007. [E-pub ahead of print]. PMID: 18057078, by Kerr J, Burke B, Petty R, Gough J, Fear D, David M, Axford J, Dalgleish A, Nutt D. St George's University of London; King's College London; Sheffield Rheumatology Centre; University of Bristol, UK. [E-mail: jkerr@sgul.ac.uk]




    Please Discuss This Article:   Post a Comment 



    [ Be the first to comment on this article ]




     
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Newsletter
    Subscribe Now!
    Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
     Privacy Guaranteed  |  View Archives

    Save on Nutritional Supplement Orders

    Featured Products

    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium

    Natural Remedies

    Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
    Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
    Breaking Through the Mental Fog Breaking Through the Mental Fog
    Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
    Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask

    FIBROMYALGIA RESOURCES
    What is Fibromyalgia?
    Fibromyalgia Diagnosis
    Fibromyalgia Symptoms
    Fibromyalgia Treatments
    | CFS RESOURCES
    What is CFS?
    ME/CFS Diagnosis
    ME/CFS Symptoms
    ME/CFS Treatments
    | FORUMS
    Fibromyalgia
    ME/CFS
    ADVANCED MEDICAL LABS
    WHOLESALE  |  AFFILIATES
    GUARANTEE  |  PRIVACY
    CONTACT US
    LIBRARY
    RSS
    SITE MAP
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing