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Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment - Source: Journal of Geriatric Psychiatry and Neurology, Dec 10, 2008

  [ 73 votes ]   [ Discuss This Article ]
By David J Llewellyn, et al. • www.ProHealth.com • January 22, 2009


Vitamin D may be of interest in the prevention of cognitive impairment, though previous findings are inconclusive.

Participants were 1,766 adults aged 65 years and older from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum 25-hydroxyvitamin D quartiles to cognitive impairment was modeled using logistic regression.

In all, 212 participants (12%) were cognitively impaired.

Odds ratios (95% confidence intervals) for cognitive impairment in the first (8-30 nmol/L), second (31-44 nmol/L), and third (45-65 nmol/L) quartiles of serum 25-hydroxyvitamin D compared with the fourth (66-170 nmol/L) were 2.3 (1.4-3.8), 1.4 (0.8-2.4), and 1.1 (0.6-1.9), after adjustment for age, sex, education, ethnicity, season of testing, and additional risk factors for cognitive impairment (P for linear trend = .001).

[Note: an odds ratio of 1.0 would indicate no difference in odds of cognitive impairment vs. the highest vitamin D quartile. The OR of 2.3 for the lowest vitamin D quartile indicates 130% greater odds; 1.4 indicates 40% greater odds; and 1.1 would be 10% greater odds.]

Our data suggest low serum 25-hydroxyvitamin D is associated with increased odds of cognitive impairment.

Source: Journal of Geriatric Psychiatry and Neurology, Dec 10, 2008. [E-pub ahead of print] PMID: 19073839, by Llewellyn DJ, Langa K, Lang I. Department of Public Health and Primary Care, Forvie Site, University of Cambridge, Cambridge, UK; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Public Health and Epidemiology Group, Peninsula Medical School, Exeter, UK. [E-mail: dl355@medschl.cam.ac.uk]





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