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Added Evidence Alzheimer’s Could be Type 3 ‘Diabetes of the Brain’

  [ 10 votes ]   [ 2 Comments ]
www.ProHealth.com • February 26, 2009


“Recognizing that Alzheimer’s disease is a type of brain diabetes points the way to novel discoveries that may finally result in disease-modifying treatments for this devastating disease.”

A Northwestern University-led research team reports that insulin, by shielding memory-forming synapses from harm, may slow or prevent the damage and memory loss caused by toxic proteins in Alzheimer’s disease.

The findings, which provide additional new evidence that Alzheimer’s could be due to a novel third form of diabetes, were published online Feb 10 in Proceedings of the National Academy of Sciences.* [See also the team’s video “Insulin for Alzheimer’s.”]

In a study of neurons taken from the hippocampus, one of the brain’s crucial memory centers, the scientists treated cells with insulin and the insulin-sensitizing drug rosiglitazone, which has been used to treat type 2 diabetes. (Isolated hippocampal cells are used by scientists to study memory chemistry; the cells are susceptible to damage caused by ADDLs, toxic proteins that build up in persons with Alzheimer’s disease.)

The researchers discovered that damage to neurons exposed to ADDLs was blocked by insulin, which kept ADDLs from attaching to the cells. They also found that protection by low levels of insulin was enhanced by rosiglitazone.

ADDLs (short for “amyloid beta-derived diffusible ligands”) were discovered at Northwestern and are known to attack memory-forming synapses. After ADDL binding, synapses lose their capacity to respond to incoming information, resulting in memory loss.

The protective mechanism of insulin works through a series of steps by ultimately reducing the actual number of ADDL binding sites, which in turn results in a marked reduction of ADDL attachment to synapses, the researchers report.

“Therapeutics designed to increase insulin sensitivity in the brain could provide new avenues for treating Alzheimer’s disease,” said senior author William L. Klein, director of the Klein Lab, part of Northwestern’s Weinberg College of Arts and Sciences.

“Sensitivity to insulin can decline with aging, which presents a novel risk factor for Alzheimer’s disease. Our results demonstrate that bolstering insulin signaling can protect neurons from harm.”

The amyloid beta oligomers, or ADDLs, form when snippets of a protein clump together in the brain. In Alzheimer’s disease, when ADDLs bind to nearby neurons, they cause damage from free radicals and a loss of neuronal structures crucial to brain function, including insulin receptors. This damage ultimately results in memory loss and other Alzheimer’s disease symptoms. The Alzheimer’s drug Namenda has been shown to partially protect neurons against the effects of ADDLs.

“The discovery that anti-diabetic drugs shield synapses against ADDLs offers new hope for fighting memory loss in Alzheimer’s disease,” said lead author Fernanda G. De Felice, a former visiting scientist in Klein’s lab and an associate professor at the Federal University of Rio de Janeiro, Brazil.

“Recognizing that Alzheimer’s disease is a type of brain diabetes points the way to novel discoveries that may finally result in disease-modifying treatments for this devastating disease,” adds Sergio T. Ferreira, another member of the research team and a professor of biochemistry in Rio de Janeiro.

In other recent and related work, Klein, De Felice and their colleagues showed that ADDLs bound to synapses remove insulin receptors from nerve cells, rendering those neurons insulin resistant.

The outcome of the molecular-level battle between ADDLs and insulin, which in the current PNAS study was found to remove ADDL receptors, may determine whether a person develops Alzheimer’s disease…
___
* Article (available free): “Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of amyloid beta oligomers,” Proceedings of the National Academy of Sciences, Feb 10, 2009.

Source: Northwestern University press release, Feb 2, 2009

Note: This research was supported by the Alzheimer’s Association, the American Health Assistance Foundation, the National Institute on Aging, the Howard Hughes Medical Institute, the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil), Fundacao de Amparo à Pesquisa do Estado do Rio de Janeiro (Brazil) and the Human Frontier Science Program.




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Article Comments Post a Comment

Confusion of insulin vs insulin sensitivity?
Posted by: valentinelynx
Mar 4, 2009
I have more issues with the findings of this study, but to start with I am curious about the interpretation of the statement: "Sensitivity to insulin can decline with aging, which presents a novel risk factor for Alzheimer’s disease. Our results demonstrate that bolstering insulin signaling can protect neurons from harm." Insulin signaling is NOT the same as insulin levels. The implications of the title and some of the statements in the text is that higher levels of insulin would be beneficial for preventing Alzheimer Dz. If this were true, then one would expect that sufferers of Type 2 diabetes and insulin resistance would be LESS susceptible to Alzheimer Disease, because these individuals have HIGH levels of serum insulin. I know there is other research implicating high levels of insulin as a promoter of Alzheimer Dz, and I will look these up to share. (L. Levitan, MD)
Reply Reply

Alzheimer's and Parkinson's continue to baffle
Posted by: Luryveth
Jul 17, 2011
The ravages of Alzheimer's and Parkinson's continue to baffle the medical community. While there is as yet virtually no cure for either, according to The Independent, science may have found something big. Professionals have effectively made neurons via human skin. The proof is here: Scientists create neurons from skin cells without stem cells
Reply Reply
 
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