ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Potential of Quercetin in the Treatment of Melanoma

Trimming the spare tire: Canola oil may cut belly fat

Supplementation with vitamins C and E associated with decreased risk of cognitive impairment, dement...

 
Print Page
Email Article

The mystery of herpesvirus reactivation - cracked at UNC?

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 29, 2009


Reactivation of dormant virus appears to be triggered by cells' defense against another virus.

Scientists know that some cancers are triggered by viruses, which take over cellular systems and cause uncontrolled cell growth. Doctors – and patients who get shingles late in life – have also known for many years that some viruses, particularly the herpes virus, can lie dormant in a person’s cells for long periods of time and then reactivate, causing disease. These viruses also cause significant disease in immunosuppressed people and those living with HIV/AIDS.

A recent study led by Blossom Damania, PhD, associate professor of microbiology and immunology at the University of North Carolina at Chapel Hill, focuses on the intersection of these two scientific puzzles, resulting in new discoveries about how one herpesvirus known to cause cancer may reactivate when the infected cell senses another type of virus entering it.

Damania, who is also a member of the UNC Lineberger Comprehensive Cancer Center, focused on Kaposi’s sarcoma-associated herpesvirus (KSHV), an agent associated with Kaposi’s sarcoma, primary effusion lymphoma and another syndrome called Castleman’s disease.

“We hypothesized that a secondary viral infection could serve as the trigger for KSHV, so we took cells infected with KSHV and activated immune receptor proteins called toll-like receptors that are present on the body’s cells. Toll-like receptors are the guardians of the cell and essentially function to alert the cell to the presence of an intruder. These proteins act as an alarm system to tell the cell that a foreign organism is trying to enter it,” said Damania.

Ten human toll-like receptors have been identified by scientists thus far, but the UNC team found that activation of only two of them, TLR7 and TLR8, reactivated the virus, allowing it to reproduce itself.

The cells self-destruct in an attempt to kill the virus, but by the time the cell dies, the virus has already replicated and escaped, moving on to infect other cells in the body.

“This is a very exciting finding because it helps us better understand how a latent virus can suddenly reactivate, replicating and spreading throughout the body,” said Damania. “Additionally, since Kaposi’s sarcoma is a cancer that is associated with this phase of viral infection, it is plausible that the virus’ activation and replication may eventually lead to the development of Kaposi’s sarcoma in an infected individual.

“Laboratory experiments in a controlled research environment often do not reflect the real world, where we are constantly exposed to many different environmental factors and other microorganisms. This finding is an important reminder that multiple factors are involved in causing disease,” she added.

The research was published online June 29 in the Proceedings of the National Academy of Sciences. Study co-authors from the UNC Lineberger Comprehensive Cancer Center include first-author Sean Gregory, graduate student; John West, PhD, postdoctoral fellow; Patrick Dillon, PhD, postdoctoral fellow; and Dirk Dittmer, PhD, associate professor of microbiology and immunology.

This work was supported by the National Institutes of Health, the Leukemia and Lymphoma Society and the Burroughs Wellcome Fund.

Source: University of North Carolina at Chapel Hill School of Medicine, news release June 29, 2009




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map