ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Can Ginkgo Give Your Brain a Boost?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

 
Print Page
Email Article

Key to Fat Burning vs. Obesity Discovered

  [ 83 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 5, 2010


“Therapeutic targeting of the KATP channel function, specifically in muscle, could offer a new option for obese patients with lower capacity for exercise.” - Alexey Alekseev, PhD, Mayo Clinic

Mayo Clinic researchers collaborating with investigators at the University of Iowa, University of Connecticut and New York University (NYU) have discovered a molecular mechanism that controls energy expenditure in muscles and helps determine body weight.

Researchers say this could lead to a new medical approach in treating obesity. The findings were published Jan 5 by the journal Cell Metabolism.(1)

The energy-saving mechanism is controlled by ATP-sensitive potassium (KATP) channels.

ATP, or adenosine triphosphate, is the “energy currency” utilized by cells in the body. These particular channels can sense ATP pools and regulate heart and skeletal muscle performance accordingly. Animals lacking this energy-saving mechanism burn more stored energy by dissipating more heat when at rest or when normally active.

As in humans, excess energy from food is stored as glycogen or fat that could be converted into ATP according to energy demand. Eliminating the KATP channel forces the body to use energy less efficiently, consuming more and storing less - gaining low weight, even when on a high-calorie “Western” diet.

“While mechanisms that preserve energy are naturally protective - in times of food shortage or environmental stress - they promote obesity in a sedentary, modern society,” says Alexey E. Alekseev, PhD, Mayo Clinic electrophysiologist and first author of the study.

“Our findings suggest that therapeutic targeting of the KATP channel function, specifically in muscle, could offer a new option for obese patients with lower capacity for exercise.”

How the Study was Done

Dr. Alekseev and his colleagues suspected that the KATP channel could control energy expenditure. To test the hypothesis, they studied genetically modified mice in which the KATP channel had been inactivated in the whole body or muscle tissues. They compared these mice to normal mice and found that as early as 5 months of age, the modified mice were leaner and stayed that way throughout their life span.

Researchers compared activity patterns, hormone levels, food intake, and respiratory gas exchange while at rest and under moderate exercise. A hallmark of the study was the discovery that activity in the absence of the KATP channel function resulted in increased consumption of carbohydrates and lipids. That, in turn, led to enforced burning of glycogen and stored body fat.

“By sensing cellular energy content, KATP channels continuously, at any activity level, optimize energy use and define the balance between energy availability and consumption,” explains Dr. Alekseev. “In principle, a positive energy balance favoring weight gain could be reversed by targeting muscle KATP channels to control obesity in patients with low to moderate exercise capacity imposed by the overweight state.”

The research was supported by the Gerstner Family Career Development Award in Individualized Medicine, the American Society for Clinical Pharmacology and Therapeutics, the Marriott Foundation, Mayo Graduate School, the National Institutes of Health, and, in part, by the Medical Research Initiative of the Roy J. Carver Charitable Trust and the Fraternal Order of Eagles, Iowa Aerie.

Study authors include Santiago Reyes Ramirez; Satsuki Yamada, MD, PhD.; Srinivasan Sattiraju; Marina Gerbin; and Andre Terzic, MD, PhD; all of Mayo Clinic; Denice Hodgson-Zingman, MD; Zhiyong Zhu, PhD; Ana Sierra, PhD; and Leonid Zingman, MD; all of the University of Iowa; William Coetzee, DSc, NYU School of Medicine; and David Goldhamer, PhD, University of Connecticut.
____

1. Article: "Sarcolemmal ATP-Sensitive K+ Channels Control Energy Expenditure Determining Body Weight."

Source: Mayo Clinic news release, Jan 5, 2009




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Ultra ATP+, Double Strength Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
"It's Not Easy Being Green" - But It Is Healthy
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
How I Found My Long-Lost Energy How I Found My Long-Lost Energy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map