ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplements, sleep could help manage pain

Bacopa: The Herb That May Increase Your Brain Power

Eat More Yogurt and Avoid Osteoporosis

Coffee, herbal tea may help prevent liver fibrosis

Crafty Uses for Carrot Seed Oil

Curcumin, resveratrol, ursolic acid show promise against prostate cancer

Higher omega 3 levels linked to improved brain blood flow

Olive oil compound could help protect against brain cancer

Probiotic use linked to improved symptoms of depression

How Fish Oil Benefits Heart Disease Patients with Depression

 
Print Page
Email Article

Vitamin D controls T cell antigen receptor signaling and activation of human T cells – Source: Nature Immunology, Mar 7, 2010

  [ 142 votes ]   [ Discuss This Article ]
By Marina Rode von Essen, Carsten Geisler, et al. • www.ProHealth.com • March 12, 2010


[Note: The main job of the body’s T cells is to fight infection. These Danish researchers found that when T cells encounter a pathogen, they expose a vitamin D receptor that searches for vitamin D, and they will not activate without it.]

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-?1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells.

However, TCR triggering led to an upregulation of ~75-fold in PLC-?1 expression, which correlated with greater TCR responsiveness.

Induction of PLC-?1 was dependent on vitamin D and expression of the vitamin D receptor (VDR).

Naive T cells did not express VDR, but VDR expression was induced by TCR signaling via the alternative mitogen-activated protein kinase p38 pathway.

Thus, initial TCR signaling via p38 leads to successive induction of VDR and PLC-?1, which are required for subsequent classical TCR signaling and T cell activation.

Source: Nature Immunology, Mar 7, 2010. doi:10.1038/ni.1851 by von Essen MR, Kongsbak M, Schjerling P,  Olgaard K, Odum N, Geisle C. Department of International Health, Immunology and Microbiology; Center for Healthy Aging, Faculty of Health Sciences; Department of Biology, Faculty of Science; Institute of Sports Medicine and Department of Nephrology, Bispebjerg Hospital, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark. [E-mail: cge@sund.ku.dk]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Vitamin D3 5000 IU

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 1000 IU Vitamin D3 1000 IU
Crucial nutrient for strong bones, heart and immune health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give Your Body a Boost With the Sunshine Vitamin

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map