[Note: this article, by leading IC clinican/researcher C Lowell Parsons, MD, suggests a new paradigm uniting many syndromes into "one primary disease process."]
The traditional diagnosis of interstitial cystitis (IC) only recognizes the severe form of the disease.
The far more common early and intermittent phases of the disease are not perceived to be part of IC but rather are misdiagnosed as urinary tract infection, urethral syndrome, overactive bladder, chronic prostatitis, urethritis, or a type of gynecologic pelvic pain (such as endometriosis, vulvodynia, or some type of vaginitis).
All of these patient groups actually suffer from the same bladder disease. This disease results from a leaky bladder epithelium [protective mucus lining] and subsequent potassium leakage into the bladder interstitium [surrounding / supporting tissue] that generates the symptoms of frequency, urgency, pain or incontinence in any combination.
Robust scientific data now support this important concept.
These data will be reviewed herein.
The conclusions derived from these data substantially alter the paradigms for urology and gynecology in the generation of frequency, urgency and pelvic pain.
All the above-mentioned syndromes unite into one primary disease process - lower urinary dysfunction epithelium, or LUDE disease - and not the 10 plus syndromes traditionally recognized.
Source: BJU InternationaI, Dec 22, 2010. PMID: 21176078, by Parsons CL, at UC San Diego Medical Center, Department of Surgery/Urology, La Jolla, and Division of Urology, San Diego, California, USA. [E-mail: firstname.lastname@example.org]