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Exciting Research Connects Epstein-Barr to MS Brain Lesions & Potentially Other Disorders Involving the CNS

  [ 83 votes ]   [ 5 Comments ] • January 6, 2012

Study demonstrates how EBV sequestered in the brain causes the nerve cell damage of MS – suggests it may play a role in other disorders, and may respond to rituximab, or antiviral therapies the researchers are now preparing for trial

A new study by researchers at Queen Mary, University of London shows how the Epstein-Barr virus tricks the immune system into triggering an acute inflammatory process and nerve cell damage in the brain, which is known to cause MS.

Previous research has suggested a link between the Epstein-Barr virus (EBV) and multiple sclerosis, but until now the research has remained controversial, since scientists had failed to substantiate the link.

The new study proves the virus is involved in a manner more sophisticated and subtle than previously imagined, and may offer new ways to treat or prevent the disease.

MS is a neurological condition that affects around 100,000 people in the UK. It can cause vision problems and difficulties with walking and fatigue, and tends to strike mainly young and middle-aged women.

Its root causes are not completely understood, but both genes and environment are known to play a role. Some previous research has suggested that EBV triggers MS, but subsequent studies had failed to find the connection.

The new research, published Jan 3 by the journal Neurology, looked at post mortem brains of MS patients, examining areas where neurological damage had recently occurred. (See “Association of innate immune activation with latent Epstein-Barr virus in active MS lesions.”)

Dr. Ute-Christiane Meier from Barts and the London Medical School, part of Queen Mary, led the research. She explained:

“EBV is quite a clever virus; when it’s not growing and spreading it can hide away in our immune cells... In this study we used a different technique which allowed us to detect the virus in the brains of some people affected by MS, even when it was hiding away in the cells.”

Dr Meier and her team of collaborators found that, although the virus was not actively spreading, it was releasing a chemical message into areas of the brain nearby.

This chemical message - made up of small RNA molecules - was activating the body’s immune system, causing inflammation. This damages nerve cells in the brain and causes MS symptoms.

Dr Meier continued:

“We have to be careful and have to study more MS brains, but this is potentially very exciting research. Now we understand how EBV gets smuggled into the brain by cells of the immune system and that it is found at the crime scene, right where the attack on our nervous system occurs. Now we know this, we may have a number of new ways of treating or even preventing the disease.”

Possible Target for Rituximab or Anti-Virals

One possibility is the widely-used cancer treatment Rituximab; a drug which is known to kill the cells of the immune system in which the virus hides. It is now being trialed as a treatment for MS - as well as myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS).

Another possible approach, using anti-viral treatment, will be tested in clinical trials currently in preparation by Professor Gavin Giovannoni and colleagues, also at Queen Mary.

Dr. Meier adds:

“If we can pinpoint EBV as a trigger, it’s possible that we could alter the course of MS or potentially even prevent the condition by treating the virus. MS so often strikes young women, and its unpredictable nature makes it an incredibly difficult disease to live with. We desperately need better ways to tackle the condition.”

Interestingly, the research also hinted that infection with EBV and its action on the immune system could also be playing a role in other brain diseases such as cancer (e.g., lymphoma) and stroke.

This research was supported by the Medical Research Council and MS charities, Roan Charitable Trust and Aims2Cure.

Source: Based on Queen Mary University of London press release, Jan 4, 2012

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Article Comments Post a Comment

Posted by: jacqui38
Jan 8, 2012
At last research is finally showing that people with ME that may be caused by a virus
Reply Reply

Exciting Research Connects Epstein-Barr to MS Brain Lesions & Potentially Other Disorders Involving
Posted by: jhampton
Jan 11, 2012
Very interesting Article. In 1986 I had one of the worst cases of Mono my doctor had seen. I was in my 30's. It took me a full year to feel better. My doctor said this, would, or could, show up in my blood tests for years. Ten or Eleven years later, I became ill again. My Doctor's suspected Lupus. While I didn't have all the markers for Lupus, I did have some, and, all the symptoms are there as well. They finally diagnosed me with Undifferentiated Connective Tissue Disease, Chronic Fatigue Syndrome, and, later, Systemic Fibromyalgia. Of course, I have many other health problems that are associated. What I find interesting about this report is my "Neurologist" at the time, also suspected that I might have MS. He ran a huge amount of tests, but, they were negative. Thank the Lord. However, they did find Lesions on my Brain. This was puzzling to him. He asked me if I had ever had a stroke. I have migraines, tremors, and have had several episodes that I thought were Seizure type events. I still suffer greatly from CFS, Connective Tissue Disease (Auto Immune Disease), Systemic Fibromyalgia, Chronic Pain, and all of the other health problems that are associated.
This article makes me wonder if the Epstein - Barr virus, and, Infectious mononucleosis, is what caused the Lesions on my Brain? Is there a connection? I also had several injuries to my neck, Hysterectomy, and, was under a HUGE amount of stress at work for 9 years. 5 years after my first diagnosis my health went downhill and I haven't been able to work since. It's been a life of misery ever since. I pray they find a connection so other’s never having to suffer with this disabling condition.

Thank You, ProHealth!
Reply Reply

EBV and brain lesions
Posted by: spiketheartist
Jan 11, 2012
Please think about your wording a little more carefully in the future. The fact that my Epstein-Barr virus, which I've had in at least a semi-activated state for 20 years, may be causing brain lesions isn't exactly "exciting" for me - it's terrifying. I'm glad for others who have had the EB virus for a shorter period of time that this discovery may help them, but a more moderate adjective would still have been appropriate.

It would be interesting if someone could look into and find a relationship between EBV levels and extent of brain fog so that we might surmise that the EBV-caused lesions account for our deadening brains.
Reply Reply

MS and ME
Posted by: GuidodenBroeder
Jan 18, 2012
The same mechanism can cause ME. Could the difference be nothing more than the exact location of the inflammation, perhaps caused by a slight difference in messenger molecules?


Guido den Broeder
Stichting ME Research
Reply Reply

ME/CFS and Epstein Barr
Posted by: Woodlandiaworld
Nov 5, 2012
I too had Glandular Fever just before the ME started in 1984. That was the trigger for me. I now have severe autonomic neuropathy. I think around 80% of ME/CFS sufferers have Epstein Barr before the ME starts. There is definitely a link.
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