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Devin Starlanyl On Medications For Fibromyalgia

  [ 2592 votes ]   [ 4 Comments ]
By Devin Starlanyl • • June 27, 2006

Often, you may have to try many medications before you find the optimum ones for you. We react differently to each medication, and there is no "cookbook recipe" for FMS (fibromyalgia syndrome) or MPS (myofascial pain syndrome). What works well for one of us can be ineffective for another. A medication which puts one person to sleep may keep another awake. Each of us has our unique combination of neurotransmitter disruption and connective tissue disturbance. We need doctors who are willing to stick with us until an acceptable symptom relief level is reached. These are not the only medications in use for FMS & MPS, but are simply a selection to show what is available. It may be necessary to address each perpetuating factor, such as pain, lack of restorative sleep, and muscle rigidity, separately. Medications should be used along with a program of proper diet, life style changes, mind work and bodywork. Medications which affect the central nervous system are appropriate for FMS&MPS Complex. They target symptoms of sleep lack, muscle rigidity, pain and fatigue. Pain sensations are amplified by FMS, and so the pain of MPS pain is multiplied. FMS&MPS Complex patients often react oddly to medications. It is the rule rather than the exception that a FMS&MPS Complex patient will save strong pain meds from surgery or injury for when they REALLY need it -- for an FMS&MPS Complex "flare". This is a sign that your needs aren't being met. I give you the following quotes. I hope you will pass them on to your doctor. They are from "PAIN A Clinical Manual for Nursing Practice", by McCaffrey and Beebe. * Health professionals "often are unaware of their lack of knowledge about pain control." * "The health team's reaction to a patient with chronic nonmalignant pain may present an impossible dilemma for the patient. If the patient expresses his depression, the health team may believe the pain is psychogenic or is largely an emotional problem. If the patient tries to hide the depression by being cheerful, the health team may not believe that pain is a significant problem." * "Research shows that, unfortunately, as pain continues through the years, the patient's own internal narcotics, endorphins, decrease and the patient perceives even greater pain from the same stimuli." * "The person with pain is the only authority about the existence and nature of that pain, since the sensation of pain can be felt only by the person who has it." * "Having an emotional reaction to pain does not mean that pain is caused by an emotional problem." * "Pain tolerance is the individual's unique response, varying between patients and varying in the same patient from one situation to another." "Respect for the patient's pain tolerance is crucial for adequate pain control." * "THERE IS NOT A SHRED OF EVIDENCE ANYWHERE TO JUSTIFY USING A PLACEBO TO DIAGNOSE MALINGERING OR PSYCHOGENIC PAIN." * "No evidence supports fear of addiction as a reason for withholding narcotics when they are indicated for pain relief. All studies show that regardless of doses or length of time on narcotics, the incidence of addiction is less than 1%." This book is so clear and so well documented that I suggested my local library buy it. I wanted everyone in the area to have access to this information. Once you read this book, you get a greater understanding of pain and pain medications, as well as coping mechanisms. Many non-pharmaceutical methods of pain control are also described thoroughly in this reference. It's normal to be depressed with chronic pain, but that doesn't mean depression is causing the pain. Maintenance with mild narcotics (Darvocet, Tylenol #3, Vicodin-Lorcet-Lortab) for nonmalignant (non-cancerous) chronic pain conditions be a humane alternative if other reasonable attempts at pain control have failed. The main problem with raised dosages of these medications is not with the narcotic components, per se, but with the aspirin or acetaminophen that is often compounded with them. For medical journal documentation on the use of narcotics for non-malignant chronic pain, see "The Fibromyalgia Advocate". Narcotics should not be given in conjunction with benzodiazepines, as the latter antagonize opioid analgesia. Narcotic analgesics are sometimes more easily tolerated than NSAIDS, the Non-Steroidal Anti-Inflammatory Drugs. Neither FMS nor MPS is inflammatory. NSAIDS may disrupt stage 4 sleep. Prolonged use of narcotics may result in physiological changes of tolerance or physical dependence (with- drawal), but these are not the same as psychological dependence (addiction). Under-treatment of chronic pain of MPS/FMS results in a worsening contraction which results in even more pain. "Anti- anxiety" medications are not an indication that your symptoms are "all in the head". These medications don't stop the alpha-wave intrusion into delta-level sleep, but they extend quantity of sleep, and may ease daytime symptom "flares". Folic acid: This vitamin is often in short supply in FMS & MPS. Drs. Travell and Simons found it especially effective for Restless Leg Syndrome. Relafen (nambumetone):This is a NSAID that is often well tolerated because it is absorbed in the intestine, sparing the stomach. Benedryl (dyphenhydramine):a helpful sleep aid/antihistamine which is safe in pregnancy. This should be the first sleep medication tried. Some patients have reported urinary retention. The starting dose is 50 mg 1 hr. before bed. Increase as tolerated until symptoms are controlled or 300 mgs. About 20% of patients react with excitation rather than sedation when taking Benadryl. (non-prescription) Desyrel (Trazodone): an antidepressant that helps with sleep problems. It must be taken with food. Atarax (hydroxyzine HCl): suppresses activity in some areas of Central Nervous System to produce an anti-anxiety effect. This antihistamine and anxiety-reliever may be useful when itching is a problem. Elavil (amitriptyline): a tricyclic antidepressant (TCA) is cheap and sometimes useful. It generates a deep stage four sleep. Most patients will adapt to this med after a few weeks. It can cause photosensitivity and morning grogginess. It often causes weight gain, dry mouth, as well as stopping the normal movements of the intestine. It may cause Restless Leg Syndrome. Wellbutrin (bupropion HCl): is a weak Specific Serotonin Reuptake Inhibitor (SSRI) and antidepressant that is sometimes used in FMS & MPS Complex in place of Elavil. It can promote seizures. It seems to be less likely to promote sexual dysfunction than the most SSRIs. Ambien (zolpidem tartate): hypnotic -- sleeping pill, for short-term use for insomnia. There have been reports of serious depression, but some people with FMS find it allows them to experience restorative sleep. Soma (carisoprodol): acts on Central Nervous System to relax muscles, not on the muscles themselves. It works rapidly and lasts from 4 to 6 hrs. It helps detach from pain, and modulates erratic neurotransmitter traffic, damping the sensory overload of FMS and muscular rigidity of MPS. Flexeril (cyclobensaprine): this medication can sometimes stop spasms, twitches and some tightness of the muscle. It is related chemically to Elavil. It generates stage four sleep, but it may cause gastric upset and a feeling of detachment from life. Sinequan (doxepin): heterotricyclic antidepressant and antihistamine. It can produce marked sedation. This medication may enhance Klonopin, but can reduce muscle twitching by itself. Prozac (fluoxetine hydrochloride): anti-depressant that increases the availability of serotonin, useful for those patients who sleep excessively, have severe depression and overwhelming fatigue. Some people have reported profound depression from Prozac. Ultram (tramadol): non-narcotic, Central Nervous System medication for moderate to severe pain, in a new class of analgesics called CABAs -- Centrally Acting Binary Agents. Many people said it brought more alertness for longer times, and less "fibrofumble" of the fingers. It can lower the seizure threshold. Side-effects reported are grogginess, insomnia (may not be able to take at night), headache or loss of sex drive. Some people have reported profound depression resulting from Ultram. Hydrocodone/Guaifenisen Syrup: This medication is generally given as a cough suppressant. Each teaspoon contains 5 mg. Hydrocodone and 100 mg Guaifenisen. It has no aspirin or ibuprofen. It may be effective for pain medication, and can be "titrated" because it is in syrup form. The patient can take very small amounts and can find the amount which works without causing undue side effects." Xanax (alprazolam):an anti-anxiety medication, that may be enhanced by ibuprofen. It must not be used in pregnancy. It enhances the formation of blood platelets, which store serotonin, and also raises the seizure threshold. When stopping this medication, you must taper it very gradually. EMLA: a prescription only topical cream, that may help cutaneous TrPs. It is a mixture of topical anesthetics. Pamelor (nortriptyline):this is used to help sleep. Some people find it stimulating, and must take it in the morning. Others use it before bed to help sleep. Some reports of depression with use. Klonopin (clonazepam): anti-anxiety medication and anticonvulsive/ antispasmodic. It is useful in dealing with muscle twitching, Restless Leg Syndrome and nighttime grinding of teeth. BuSpar (buspirone HCl): may improve memory, reduce anxiety, helps regulate body temperature, and is not as sedating as many other anti-anxiety drugs. This medication often takes a few weeks to take effect. Zoloft (sertraline):this is an SSRI and antidepressant, and is commonly used to help sleep. It has less of an effect on liver enzymes than other SSRIs. Tagamet, Zantac, Prilosec, Axid: often used to counter esophageal reflux. Tagamet may increase stage 4 sleep, and enhance Elavil. Acid suppressors may interfere with B-12 absorption. Paxil (paroxetine HCl):serotonin and norepinephrine reuptake inhibitor, and may reduce pain. It should not be used with other meds that also increase brain serotonin. Suggested dosage is 10 mgs (half a scored tablet) may cause insomnia or drowsiness. Effexor (venlafaxine HCl):Fast acting antidepressant and serotonin and norepinephrine reuptake inhibitor. Suggested trial dosage is 25 mg, taken in the morning. Food has no affect on its absorption. When discontinuing this medication, taper off slowly. May raise blood pressure. Inderal (propranolol HCl):sometimes helps in the prevention of migraine headaches, although blood pressure may drop with its use. Antacids will block its effect, and should not be used. May be very useful in decreasing "adrenalin rush". Librax: for Irritable Bowel Syndrome. It is a combination of antispasmodic plus tranquilizer, that helps modulate bowel action. Diflucan (fluconazole): this antifungal penetrates all of the body's tissues, even the central nervous system. Very short term use can be considered if cognitive problems and/or depression is present, and yeast is suspected. Yeast may also be at the root of irritable bowel, sleep dysfunction (muramyl dipeptides from bowel bacteria induce sleep), and other common FMS problems. Imitrex (sumatriptan): this is available as an injectable solution or pill that will not prevent migraines, but it is effective for migraine pain in many cases. Works on serotonin release instead of blood vessel spasm, and may provide relief in less than 20 minutes. It should not be used within 24 hours of ergot (a common migraine drug) medications. It can increase blood pressure. It may cause spasm of muscles in jaw, neck, shoulders and arms. Also reported were tingling sensations, rapid heartbeat and the "shakes". Frequent use of Imitrex may cause a rebound reaction, worsening migraines. Remeron (mirtazapine): tetracyclic antidepressant, which effects several neurotransmitters, including serotonin and norepinephrine. May cause drowsiness and/or weight gain. Reported increase in cholesterol with some patients. Zanaflex (tizanidine): is a relatively new medication for muscle tightness and pain. It also reduces muscle spasm frequency and myoclonus. Effective dosage varies considerably in patients. May cause drowsiness." COX-2 inhibitors:These medications will be out shortly. They block cyclooxygenase-2, an enzyme that helps create enormous mounts of prostaglandins. they not only seem to be effective for inflammation (FMS & MPS are not inflammatory), but they may be a promising alternative to narcotics for pain relief. (c) Devin Starlanyl.

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Article Comments Post a Comment

It's good to know about certain medications
Posted by: charming
Apr 2, 2008
I use one medication Pamelor (Nortriptyline HCL) AND IT WORKS FOR ME AS A muscle relaxer and a sleep aide . I seen other medications that could be another alternative if this medication stop being effective but for now I will stick too nortriptyline. because its seem to help along with other pain medications which so far I have not seen on the list. Which is gabapentin I use it for nerve pain and it works for me very well alone if I take this medication I will not take the nortriptyline because it is just too much because it makes me too sleepy for the whole day so if I miss a few dose of the nortriptyline I will take it when I don't have the gabapentin in my system. I also realize that nortriptyline if not taken for 3 days my joints become stiff and swollen ,so I make sure that nortriptyline is my primary medication for FMS.
Reply Reply

Feedback on some of the above-mentioned drugs, and alternative approaches
Posted by: sarasvati
Dec 29, 2008
If you look at the Fibromyalgia Network News' Survey of Readers of what helps them the most with FMS, you will find that acupuncture and massage top the list. Although tricyclic antidepressants are a little ways down, SSRIs don't even make it on the list! I was put on Zoloft after being diagnosed and it helped me sleep 8 hours a night, but after six months I became very depressed, and no one seemed to make the connection that I might be on the wrong medication. 18 months later I was switched to Paxil. Both of these drugs turned me into a shadow of my former self; I became very self-indulgent and gained a lot of weight, and literally was a different person. After 4 years of this a young intern said I could try St. John's Wort (Hypericum) instead, and almost immediately I began to feel like my normal self again. If you have FMS, I would advise you not to take SSRIs (Prozac, Paxil, Zoloft, etc.). Elavil before bed works better and doesn't turn you into a different person! You might have to play with the dose a bit so you don't sleep too much. 37 mgs works best for me; 50 was too much. St. John's Wort is good for a while, but the body can build tolerance to herbs so you may have to stop it periodically for a month or two. When I tried Flexeril, I didn't notice any difference from it at all. As for Ambien, I was so spaced out in the afternoon I could barely function. What really helped me sleep deeply and recuperate more was Diazepam, first 5 mg. at night, and then I increased to 10 mg. at night. It worked great for a year, but then I started to feel a bit numbed so I stopped taking it. I take Neurontin (Gabapentin) only when absolutely necessary for pain; it works wonderfully, but it sure messes up your memory, spaces you out and makes you feel stupid. I'm ready to try something else for pain. For extra energy and endurance, try Rhodiola Rosea, a root extract. It helps a lot of people and is a really good thing for any kind of stress. The only negative side effect it seems to have is agitation if you take too much. Increase gradually, starting with 100mg. before breakfast for a week or so, then adding 100 mg. before lunch, then an extra 100 before breakfast, then an extra 100 before lunch if your body can handle it. (Some people are extra-sensitive to this and have to take less than 100 mg/day, whereas others can handle up to 600 mg/day. Don't take it after mid-afternoon though.) Sam-e is a supplement known to help the body create serotonin, and is even sometimes recommended by psychiatrists. It's a bit expensive as far as supplements go. An acupuncturist gave me a Chinese herbal supplement for sleep that was pretty helpful for a while. Don't hesitate to change medications or approaches. If your doctor doesn't know much about FMS, find a different doctor! Support groups are good, as living with an invisible illness in this world can be brutal.
Reply Reply

Posted by: womanpreacher
Aug 23, 2009
FMS diagnosed 1997 - major flare now after having back surg a month ago. Dr put me on Savella. Haven't started yet because it's so new and lots of side affects. Would I be better off with Cymbalta or Lyrica. Thanks.


Posted by: womanpreacher
Aug 23, 2009
FMS diagnosed 1997 - major flare now after having back surg a month ago. Dr put me on Savella. Haven't started yet because it's so new and lots of side affects. Would I be better off with Cymbalta or Lyrica. Thanks.


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