ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

'Subclinical’ B-12 deficiency - very common in older adults & may be related to cognitive decline

  [ 15 votes ]   [ Post a Comment ]
www.ProHealth.com • February 27, 2012

previous article next article

Article:
Subclinical cobalamin [B-12] deficiency
– Source: Current Opinion in Gastroenterology, Mar 2012

By Ralph Carmel

[Note: cobalamin is vitamin B-12. “Normal” findings on serum B12 tests actually leave a large gray area between definitely deficient (clinical deficiency) and definitely sufficient. Cases of deficiencies within that gray area appear often associated with cognitive decline.]

Abstract:
Purpose of review: This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.

Recent findings: Diagnosis of subclinical cobalamin deficiency depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic research.

The causes of subclinical cobalamin deficiency are unknown in more than 60% of cases, which limits prognostic predictions and identification of health consequences.

After years of varying, often inconclusive associations, new clinical trials suggest that homocysteine [a risk marker for cardiovascular disease, Alzheimer’s & Parkinson’s] reduction by high doses of folic acid [B-9]), cobalamin [B-12], and pyridoxine [B-6] may reduce progression of structural brain changes and cognitive impairment, especially in predisposed individuals.

• The causative or contributory roles, if any, of subclinical cobalamin deficiency itself in cognitive dysfunction require direct study.

• If the findings are confirmed, high-dose supplementation with three vitamins will probably be more effective than fortification of the diet.

Summary: The story of subclinical cobalamin deficiency which is severalfold times more common in the elderly than clinical cobalamin deficiency, but also differs from it in arising only infrequently from severe malabsorption and thus being less likely to progress, continues to evolve.

Preventive benefits need to be confirmed and expanded, and will require fuller understanding of subclinical cobalamin deficiency pathophysiology, natural history, and health consequences.

Source: Current Opinion in Gastroenterology, Mar 2012; 28(2) pp 151–158. Carmel R. Department of Medicine, New York Methodist Hospital, Brooklyn and Weill Cornell Medical College, New York, New York, USA.
 



previous article
  Rating 3.6 (15 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing