Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Sweep Away Senile Cells

PAIN'S SECRET MESSAGE: Why Prince Didn't Need to Die

7 Natural Ways to Prevent Diabetes

8 Hacks to Slash Medication Costs

New Study Shows Optimized Curcumin Stops Inflammation

Relief from Common Digestive Distress

What Foods Can Help Fight the Risk of Chronic Inflammation?

SURVEY: Should Opioids Be Restricted for Chronic Illness?

Block The Vascular Origins Of Cognitive Decline

Curcumin: Your Secret Weapon to Speed Muscle Recovery After Intense Exercise

 
Print Page
Email Article

Abstract: Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions?

  [ 343 votes ]   [ 3 Comments ]
www.ProHealth.com • May 26, 2004


Neuroendocrinol Lett. 2004 Feb-Apr;25(1/2):31-39. Russo EB. Senior Medical Advisor, GW Pharmaceuticals, 2235 Wylie Avenue, Missoula, MT 59802, USA. erusso@montanadsl.net

OBJECTIVES: This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.

METHODS: Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources.

RESULTS: Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.

CONCLUSION: Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.

PMID: 15159679 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

YES, I kept telling my doctor cannabis helps in so many ways!
Posted by: firstrala
Dec 13, 2007
I am also bipolar and have been on many LEGAL medications for bipolar, fibromyalgia, IBS and nothing worked or had such drastic side effects, I had to stop. After 3 years and seven months 'clean', I began to treat the anxiety and fibro pain with cannabis. Not only am I able to function much better without as much pain, my IBS symptoms are GONE. I haven't had an ER visit since!! KEEP LEARNING AND RESEARCH ALIVE! Short term memory problems are a side effect I can live with.
Reply Reply

forget what u know about cannabis
Posted by: kikky
Apr 13, 2009
I have used cannabis for appetite stimulation and to help manage stress for years. It would not surprise me that there are many other applications. I am in excellent health and can say the myths surrounding cannabis use are just the result of decades of negative propoganda aimed to secure the cotton industry's future. Short term memory loss is not a permanent side affect.
Reply Reply

Short Term Memory Loss
Posted by: rasmarcus
Mar 14, 2010
The "side effect" of short term memory loss is now being considered to be a preventitive measure for Alzheimer’s. See more.. http://www.msnbc.msn.com/id/15145917/
Reply Reply


Post a Comment

 
20 Helpful Tips for Cleaning and Organizing When You're Chronically Ill

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map