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Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers - Source: Journal of Cardiovascular Pharmacology and Therapeutics, Sep 2007

  [ 146 votes ]   [ Discuss This Article ]
By AP Shah, et al. • • September 24, 2007

[The endothelium is the lining of the circulatory system and is involved in control of vessel constriction and dilation - wider vessels allow lower blood pressure.]

Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [+/- SD] 31 +/- 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days.

At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound.

Fish oil supplementation resulted in a significant increase in EDV (20.4% +/- 13.2% vs 9.9% +/- 5.4%; P = .036) and EIDV (32.6% +/- 16.8% vs 18.0% +/- 14.9%; P = .043).

Resting HR decreased by a mean of 5.9 +/- 9.4 bpm (fish oil) compared with placebo (mean increase of 0.73 +/- 4.8 bpm [P = .05]).

Fish oil supplementation in healthy subjects is associated with improved endothelial function and decreased resting heart rate.

Source: Journal of Cardiovascular Pharmacology and Therapeutics. 2007 Sep;12(3):213-9. PMID: 17875948, by Shah AP, Ichiuji AM, Han JK, Traina M, El-Bialy A, Meymandi SK, Wachsner RY. David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. [E-mail:]

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