ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Basic Aromatherapy to Help Balance and Calm

Tea drinkers have lower glaucoma risk

Wonderful White Tea: A Drink Fit for an Emperor

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Acid Reflux May Respond Better to Foods Than Prescribed Pills

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract – Source: Emerging Infectious Diseases, expedited release May 18, 2010

  [ 224 votes ]   [ Discuss This Article ]
By Nicole Fisher, et al. • www.ProHealth.com • May 18, 2010


[Note: The Centers for Disease Control & Prevention (CDC) has expedited the release of this research, reporting evidence of XMRV in the respiratory tract secretions of 2% to 10% of patients presenting with respiratory tract infections (and 3% of control subjects) in a German study. A full text PDF is available free at www.cdc.gov/eid/content/16/6/pdfs/10-0066.pdf ]

[Abstract/Introduction:]
Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2% - 3% of samples from 168 immunocompetent carriers and about 10% of samples from 161 immunocompromised patients.

[Note: Specifically, of the 329 individuals tested for XMRV in this study:

• 62 were controls with no respiratory tract infection (RTI), of whom 2 (3.2%) were XMRV positive (all residents of North Germany).

• 75 had an RTI with no underlying condition, of whom 3 (2.3%) were XMRV positive (this group of people had traveled to Germany from Asia, permanent residency not recorded).

• 31 had an RTI with underlying chronic obstructive pulmonary disease (COPD), of whom 1 (2.3%) was XMRV positive (all residents of North Germany).

• 161 had RTI with immnosuppression owing to organ or bone marrow transplantation, of whom 16 (9.9%) were XMRV positive (all residents of North Germany).]

Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) was originally discovered in tissue from patients with familial prostate cancer homozygous for a missense mutation in the RNase L gene, R462Q. Detection of viral nucleic acid in tissue sections of cancerous prostate glands and cloning of the viral integration sites confirmed XMRV as a bona fide human infection with a murine leukemia virus-related retrovirus. Whether XMRV is actively involved in prostate cancer tumorigenesis or whether it is just a bystander virus remains unclear.

On the basis of its close homology (up to 94% nt identity) to endogenous and exogenous full-length sequences from Mus musculus mice, XMRV most likely originated in mice, although they are probably not the current reservoir of infection.

Recent findings of XMRV sequences in up to 67% of peripheral blood mononuclear cells (PBMCs) of patients with chronic fatigue syndrome and in 3.4% of PBMCs of healthy controls raise the question whether XMRV could be a blood-borne pathogen. However, the finding of XMRV in PBMCs from patients with chronic fatigue syndrome is controversial because multiple studies in Europe have failed to detect XMRV.

Similarly, frequency of XMRV in prostate cancer samples ranges from 0 to 23%, depending on geographic restriction of the virus or, more likely, diagnostic techniques used (PCR, quantitative PCR, immunohistochemistry). Indirect evidence has suggested sexual transmission.

Questions remain about worldwide distribution, host range, transmission routes, and organ tropism of the virus. To begin to answer some of them, we looked for XMRV in respiratory samples from 267 patients with respiratory tract infection (RTI) and 62 healthy persons….

Source: Emerging Infectious Diseases, Jun 2010, expedited release May 18, 2010. Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, Aepfelbacher M. University Medical Center Hamburg-Eppendorf, Hamburg; Robert Koch-Institute, Berlin; Leibniz-Center for Medicine and Biosciences, Borstel; University of Bonn Medical Centre, Bonn, Germany. [Email: nfischer@uke.de]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map