ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Repeated Detection of Infectious Xenotropic Murine Virus-Related Virus (XMRV) in Human Neoplasia and Neuroimmune Diseases – Source: 12th Intl. Conf. on Malignancies in AIDS and Other Acquired Immunodeficiences, Apr 26, 2010

  [ 20 votes ]   [ Discuss This Article ]
By Francis Ruscetti, Vincent Lombardi, Max Pfost, Kathryn Hagen, Judy Mikovits • www.ProHealth.com • July 27, 2010


(Note: This abstract, of a presentation given April 26 by National Cancer Institute researcher Frank Ruscetti, is listed in the conference agenda & program book  as “Pathogenic Consequences of Xenotropic Murine Virus-Related Virus (XMRV) Expression in the Development of Chronic Diseases.” “Neoplasia” refers to abnormal tissue proliferation, as in a tumor.)

Background: In 2006, sequences of a novel human retrovirus, XMRV, were identified and reported to be associated with a subset of hereditary prostate cancer. Although the public health implications of this finding were not immediately clear, two recent papers show XMRV is clearly a health concern.

• One clearly shows that XMRV expression in the proliferating prostate stroma and epithelium of prostate cancer patients [1].

• The second describes the detection of XMRV in about two-thirds of patients diagnosed with chronic fatigue syndrome [2].

We will present data that in these and other neuroimmune diseases and cancers, the host mounts a humoral response [involving antibodies] to XMRV and infected patients are viremic [virus particles in the bloodstream].

Methods: A combination of classical retroviral methods, including RT-PCR, full-length genomic sequencing, immunoblotting of viral expression in activated PBMC, passage of infectious virus in plasma and PBMC to indicator cell lines, and presence of antibodies to XMRV in plasma, allowed XMRV detection in more than 75% of the CFS patients studied.

Since then, several publications in Europe using DNA-PCR of blood products failed to detect XMRV sequences in patients with either disease and have created considerable controversy. Reliable methods for the biological and molecular amplification to detect XMRV in unstimulated blood cells and plasma have been developed.

Some DNA-PCR negative patient blood samples represent false negatives, and molecular analysis using DNA from unstimulated blood cells is not yet sufficient for XMRV identification.

Results: In mice, viruses related to XMRV cause B-cell lymphoma usually by insertional mutagenesis activating a cellular oncogene as well as causing chronic neurological diseases.

We will present a case of development of such B cell lymphoma in CFS patients.
XMRV-infected individuals with both neuroimmune disease and cancer develop an immune response to XMRV.

The isolation of infectious XMRV from prostate cancer patients will be shown for the first time. Pathogenic consequences of this infection will be discussed

Conclusion: XMRV, a retrovirus of unknown pathogenic potential, is infectious in humans.

References:
1. Schlaberg et al.: "XMRV is present in malignant prostate epithelium and is associated with prostate cancer." Proc Natl Acad Sci U S A 106:16351, 2009.
2. Lombardi et al.: "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome." Science 326:585, 2009.

Source: Ruscetti F, Lombardi V, Pfost M, Hagen K, Mikovits J. Laboratory of Experimental Immunology, NCI-Frederick, Frederick, Maryland; Whittemore-Peterson Institute, University of Nevada, Reno, Nevada, USA





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Live Without Anxiety or Stress Live Without Anxiety or Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map