Recently, studies have investigated the significance of the Wnt/beta-catenin pathway in prostate cancer. The transcriptional activity of the androgen receptor (AR) is modulated by interaction with coregulators, one of which is beta-catenin.
Curcumin, a dietary yellow pigment of Curcuma longa, has emerged as having a chemopreventive role. Although curcumin has been shown to inhibit AR expression, its molecular mechanism has not been fully elucidated.
In this study, whether curcumin mediates the Wnt/beta-catenin signaling pathway with regard to AR/beta-catenin interactions was studied.
• Curcumin was shown to induce significant inhibition of AR expression in a dose-dependent manner. [Higher dose, more inhibition.]
• Marked curcumin-induced suppression of beta-catenin was shown in the nuclear and cytoplasmic extracts as well as whole cell lysates.
• Further analysis revealed that phosphorylation of Akt and glycogen synthase kinase-3beta were attenuated, but phosphorylated beta-catenin was increased after curcumin treatment.
• Finally, cyclin D1 and c-myc, the target gene of the beta-catenin/T-cell factor transcriptional complex, were also decreased.
Source: Prostate Cancer and Prostatic Diseases, Aug 3 2010. PMID: 20680030, by Choi HY, Lim JE, Hong JH. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. [E-mail: email@example.com]